Several artificial anthraquinone-carbohydrate hybrids were designed and synthesized. A selectednumber of hybrids did bind to DNA via intercalation in a sequence-selective manner, leading to inhibitionof DNA cleavage by DNase I, whereas other hybrids cleaved DNA with base selectivity upon photoirradiation.This hybrid system was found to be very important for both DNA binding and photocleaving.
|Title of host publication||Anthracycline Chemistry and Biology I|
|Subtitle of host publication||Biological Occurence and Biosynthesis, Synthesis and Chemistry|
|Number of pages||14|
|Publication status||Published - 2008 Dec 1|
|Name||Topics in Current Chemistry|
ASJC Scopus subject areas