[Nontypeable Haemophilus influenzae (NTHi) epidemiology].

Keisuke Sunakawa, Yuriko Takeuchi, Satoshi Iwata

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


While most systemic pediatric Haemophilus influenzae infections are caused by the type b strain (Hib), nontypeable H. influenzae: (NTHi) has been considered a respiratory tract pathogen common in local infection such as acute otitis media, acute pneumonia, secondary chronic respiratory disease and other otorhinolaryngologic infections. Recent findings show, however, that NTHi also causes invasive infections such as meningitis, bacteremia, and lower respiratory tract infections such as pneumonia. A review of NTHi epidemiology from the 1990s onward shows that NTHi causes significant morbidity in pediatric acute otitis media, sinusitis, conjunctivitis and lower respiratory diseases such as pneumonia in Japan. This summary also reviews the worldwide influence of Streptococcus pneumoniae and Hib vaccines on causative pathogens, and several studies about increasing incidence of invasive infections due to NTHi. This review also touches on the emergence of treatment- and drug-resistant H. influenzae, which are now major public health challenges. As a cause of bacterial pediatric infection, NTHi is an important target for prevention.

Original languageEnglish
Pages (from-to)227-237
Number of pages11
JournalKansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Issue number3
Publication statusPublished - 2011 May
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of '[Nontypeable Haemophilus influenzae (NTHi) epidemiology].'. Together they form a unique fingerprint.

Cite this