@article{fcb1fc2c8b194560b367a0913aa8991b,
title = "Novel Antidepressants in the Pipeline (Phase II and III): A Systematic Review of the US Clinical Trials Registry",
abstract = "Introduction There is an imminent need for faster-acting and more effective antidepressants beyond the monoaminergic hypothesis. Methods We systematically searched the US Clinical Trials registry for antidepressant compounds with completed phase II and III trials. Compounds that demonstrated significant superiority over placebo in the primary outcome measure in the latest phase of phase II and III trials were identified. The collateral information was gathered via a PubMed search and press releases. Results Nine compounds were identified. AXS-05 (a combination of dextromethorphan and bupropion) and ansofaxine hydrochloride showed a positive result over placebo in a phase III study for major depressive disorder or treatment-resistant depression. MIJ821, nitrous oxide, psilocybin, ayahuasca, facial injection of botulinum toxin A, prasterone, and casopitant demonstrated at least one positive result in phase II trials. Ayahuasca showed a greater response rate than placebo at week one, indicating the rapid antidepressant effect. Discussion These new compounds with novel mechanisms of action are expected to provide a greater variety of treatment options for depression if preliminary positive results are confirmed.",
keywords = "antidepressant, depression, fast-acting, pipeline, treatment-resistant depression",
author = "Hitoshi Sakurai and Kengo Yonezawa and Hideaki Tani and Masaru Mimura and Michael Bauer and Hiroyuki Uchida",
note = "Funding Information: Dr. Sakurai reports grants from the Uehara Memorial Foundation and manuscript fees or speaker{\textquoteright}s honoraria from Eisai, Meiji Seika Pharma, Shionogi Pharma, Sumitomo Dainippon Pharma, Takeda Pharma, and Yoshitomi Yakuhin. Dr. Yonezawa has nothing to declare. Dr. Tani received a fellowship from the Japanese Society of Clinical Neuropsychopharmacology and the Canadian Institutes of Health Research, a research grant from Eli Lilly, and manuscript fees from Dainippon Sumitomo Pharma, Otsuka Pharmaceutical, Wiley Japan, and Yoshitomi Yakuhin. Dr. Mimura has received speaker{\textquoteright}s honoraria from Byer Pharmaceutical, Daiichi Sankyo, Dainippon-Sumitomo Pharma, Eisai, Eli Lilly, Fuji Film RI Pharma, Hisamitsu Pharmaceutical, Janssen Pharmaceutical, Kyowa Pharmaceutical, Mochida Pharmaceutical, MSD, Mylan EPD, Nihon Medi-physics, Nippon Chemipher, Novartis Pharma, Ono Yakuhin, Otsuka Pharmaceutical, Pfizer, Santen Pharmaceutical, Shire Japan, Takeda Yakuhin, Tsumura, and Yoshitomi Yakuhin within the past three years. Also, he received grants from Daiichi Sankyo, Eisai, Pfizer, Shionogi, Takeda, Tanabe Mitsubishi, and Tsumura within the past three years outside the submitted work. Dr. Bauer has received institutional funding/grant support from Deutsche Forschungsgemeinschaft (DFG), Bundesministeriums f{\"u}r Bildung und Forschung (BMBF), and the European Commission. He has received speaker honoraria and/or travel compensation from Aristo, Hexal AG, Janssen Pharmaceutica NV, Janssen-Cilag, and Sunovion. He has served on advisory boards or honoraria for consultancy from GH Research, Janssen-Cilag, Neuraxpharm, Novartis, Sandoz, Shire International GmbH, Sumitomo Dainippon, Sunovion, and Takeda. Dr. Uchida has received grants from Eisai, Otsuka Pharmaceutical, Dainippon-Sumitomo Pharma, Daiichi Sankyo Company, Mochida Pharmaceutical, and Meiji-Seika Pharma; speaker{\textquoteright}s honoraria from Otsuka Pharmaceutical, Dainippon-Sumitomo Pharma, Eisai, and Meiji-Seika Pharma, and advisory panel payments from Dainippon-Sumitomo Pharma within the past 3 years. Publisher Copyright: {\textcopyright} 2022 Georg Thieme Verlag. All rights reserved.",
year = "2022",
month = jul,
day = "1",
doi = "10.1055/a-1714-9097",
language = "English",
volume = "55",
pages = "193--202",
journal = "Pharmacopsychiatry",
issn = "0176-3679",
publisher = "Georg Thieme Verlag",
number = "4",
}
