Novel aromatic substances, dictyomedin A and B, from Dictyostelium cellular slime molds and their inhibitory effects on Dictyostelium development

Yoshiaki Takaya; Haruhisa Kikuchi; Yuichi Terui; Jun Komiya; Yasuo Maeda; Akira Ito; Yoshiteru Oshima

doi:10.1016/S0040-4039(00)01879-7

Novel aromatic substances, dictyomedin A and B, from Dictyostelium cellular slime molds and their inhibitory effects on Dictyostelium development

Yoshiaki Takaya, Haruhisa Kikuchi, Yuichi Terui, Jun Komiya, Yasuo Maeda, Akira Ito, Yoshiteru Oshima

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

To elucidate the diversity of secondary metabolites of Dictyostelium cellular slime molds and search for physiologically active substances affecting their development, we investigated the constituents of D. medium. From the methanol extract of its fruit body, we obtained two novel aromatic compounds named dictyomedin A (1) and B (2), and their structures were elucidated by means of physicochemical data. Biological evaluation of the compounds showed that they delayed the differentiation of D. discoideum cells.

Original language	English
Pages (from-to)	61-63
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/S0040-4039(00)01879-7
Publication status	Published - 2001 Jan 1
Externally published	Yes

Keywords

Cellular slime molds
Dibenzofuran
Dictyostelium medium
Differentiation inhibitor

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)01879-7

Cite this

@article{9c5c17ed477046e2a9adce5ee710d7c9,

title = "Novel aromatic substances, dictyomedin A and B, from Dictyostelium cellular slime molds and their inhibitory effects on Dictyostelium development",

abstract = "To elucidate the diversity of secondary metabolites of Dictyostelium cellular slime molds and search for physiologically active substances affecting their development, we investigated the constituents of D. medium. From the methanol extract of its fruit body, we obtained two novel aromatic compounds named dictyomedin A (1) and B (2), and their structures were elucidated by means of physicochemical data. Biological evaluation of the compounds showed that they delayed the differentiation of D. discoideum cells.",

keywords = "Cellular slime molds, Dibenzofuran, Dictyostelium medium, Differentiation inhibitor",

author = "Yoshiaki Takaya and Haruhisa Kikuchi and Yuichi Terui and Jun Komiya and Yasuo Maeda and Akira Ito and Yoshiteru Oshima",

year = "2001",

month = jan,

day = "1",

doi = "10.1016/S0040-4039(00)01879-7",

language = "English",

volume = "42",

pages = "61--63",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "1",

}

TY - JOUR

T1 - Novel aromatic substances, dictyomedin A and B, from Dictyostelium cellular slime molds and their inhibitory effects on Dictyostelium development

AU - Takaya, Yoshiaki

AU - Kikuchi, Haruhisa

AU - Terui, Yuichi

AU - Komiya, Jun

AU - Maeda, Yasuo

AU - Ito, Akira

AU - Oshima, Yoshiteru

PY - 2001/1/1

Y1 - 2001/1/1

N2 - To elucidate the diversity of secondary metabolites of Dictyostelium cellular slime molds and search for physiologically active substances affecting their development, we investigated the constituents of D. medium. From the methanol extract of its fruit body, we obtained two novel aromatic compounds named dictyomedin A (1) and B (2), and their structures were elucidated by means of physicochemical data. Biological evaluation of the compounds showed that they delayed the differentiation of D. discoideum cells.

AB - To elucidate the diversity of secondary metabolites of Dictyostelium cellular slime molds and search for physiologically active substances affecting their development, we investigated the constituents of D. medium. From the methanol extract of its fruit body, we obtained two novel aromatic compounds named dictyomedin A (1) and B (2), and their structures were elucidated by means of physicochemical data. Biological evaluation of the compounds showed that they delayed the differentiation of D. discoideum cells.

KW - Cellular slime molds

KW - Dibenzofuran

KW - Dictyostelium medium

KW - Differentiation inhibitor

UR - http://www.scopus.com/inward/record.url?scp=0035180280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035180280&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)01879-7

DO - 10.1016/S0040-4039(00)01879-7

M3 - Article

AN - SCOPUS:0035180280

SN - 0040-4039

VL - 42

SP - 61

EP - 63

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 1

ER -

Novel aromatic substances, dictyomedin A and B, from Dictyostelium cellular slime molds and their inhibitory effects on Dictyostelium development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this