TY - JOUR
T1 - Novel chlorinated dibenzofurans isolated from the cellular slime mold, Polysphondylium filamentosum, and their biological activities
AU - Kikuchi, Haruhisa
AU - Kubohara, Yuzuru
AU - Nguyen, Van Hai
AU - Katou, Yasuhiro
AU - Oshima, Yoshiteru
N1 - Funding Information:
This work was supported in part by Grant-in-Aid for Scientific Research (No. 23710247 and 24590110 ) from the Ministry of Education, Science, Sports and Culture of Japan, and the SUNBOR GRANT from the Suntory Institute for Bioorganic Research.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Cellular slime molds are expected to have the huge potential for producing secondary metabolites including polyketides, and we have studied the diversity of secondary metabolites of cellular slime molds for their potential utilization as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium filamentosum, we obtained new chlorinated benzofurans Pf-1 (4) and Pf-2 (5) which display multiple biological activities; these include stalk cell differentiation-inducing activity in the well-studied cellular slime mold, Dictyostelium discoideum, and inhibitory activities on cell proliferation in mammalian cells and gene expression in Drosophila melanogaster.
AB - Cellular slime molds are expected to have the huge potential for producing secondary metabolites including polyketides, and we have studied the diversity of secondary metabolites of cellular slime molds for their potential utilization as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium filamentosum, we obtained new chlorinated benzofurans Pf-1 (4) and Pf-2 (5) which display multiple biological activities; these include stalk cell differentiation-inducing activity in the well-studied cellular slime mold, Dictyostelium discoideum, and inhibitory activities on cell proliferation in mammalian cells and gene expression in Drosophila melanogaster.
KW - Cellular slime molds
KW - Dibenzofuran
KW - Dictyostelium discoideum
KW - Gene expression
KW - Stalk cell differentiation
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U2 - 10.1016/j.bmc.2013.05.022
DO - 10.1016/j.bmc.2013.05.022
M3 - Article
C2 - 23746784
AN - SCOPUS:84879688018
SN - 0968-0896
VL - 21
SP - 4628
EP - 4633
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 15
ER -