Obesity, insulin resistance and the implication of thiazolidinediones

Y. Oguma, K. Kataoka

Research output: Contribution to journalReview articlepeer-review


The mechanism of insulin resistance in obesity is not fully understood. In muscle cells, the number of insulin receptor, the function of glucose transporter 4 and the activity of tyrosine kinase decrease. The rink of body fat accumulation and insulin resistance in muscle is thought through free fatty acid and tumor necrosis factor alpha secreted in adipose tissue. Thiazolidinediones (TZDs) are useful to reduce insulin resistance especially in obesity. TZDs seem to cause small weight gain, but to reduce visceral fat in 12-24 weeks. In longer period, it hasn't been studied very much. There are some unsolved problems. So now, targets of TZDs are obese diabetes failed in other medicines. When using TZDs, be cautious of excess eating and physical inactivity.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number2
Publication statusPublished - 2000 Feb

ASJC Scopus subject areas

  • General Medicine


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