Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation: Therapeutic challenges

Miki Uchino; Yoko Ogawa; Masataka Kawai; Hiroyuki Shimada; Kaori Kameyama; Shinichiro Okamoto; Murat Dogru; Kazuo Tsubota

doi:10.1111/j.1600-0420.2006.00658.x

Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation: Therapeutic challenges

Miki Uchino, Yoko Ogawa, Masataka Kawai, Hiroyuki Shimada, Kaori Kameyama, Shinichiro Okamoto, Murat Dogru, Kazuo Tsubota

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We present the first child case of pseudomembranous conjunctivitis accompanied by an extensive corneal ulcer with acute graft-versus-host disease (GVHD) after cord blood stem cell transplantation (CBSCT). The histopathology of the pseudomembrane and the ocular changes following its excision were investigated specifically. One week after the excision of pseudomembrane, the extensive corneal epithelial defects had totally disappeared. Pseudomembrane excision may be an effective method of treatment in corneal epithelial defects observed after GVHD.

Original language	English
Pages (from-to)	545-548
Number of pages	4
Journal	Acta Ophthalmologica Scandinavica
Volume	84
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0420.2006.00658.x
Publication status	Published - 2006 Aug

Keywords

Cord blood stem cell transplantation
Corneal ulcer
Graft-versus-host disease
Pseudomembrane

ASJC Scopus subject areas

Ophthalmology

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10.1111/j.1600-0420.2006.00658.x

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abstract = "We present the first child case of pseudomembranous conjunctivitis accompanied by an extensive corneal ulcer with acute graft-versus-host disease (GVHD) after cord blood stem cell transplantation (CBSCT). The histopathology of the pseudomembrane and the ocular changes following its excision were investigated specifically. One week after the excision of pseudomembrane, the extensive corneal epithelial defects had totally disappeared. Pseudomembrane excision may be an effective method of treatment in corneal epithelial defects observed after GVHD.",

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T2 - Therapeutic challenges

AU - Uchino, Miki

AU - Ogawa, Yoko

AU - Kawai, Masataka

AU - Shimada, Hiroyuki

AU - Kameyama, Kaori

AU - Okamoto, Shinichiro

AU - Dogru, Murat

AU - Tsubota, Kazuo

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AB - We present the first child case of pseudomembranous conjunctivitis accompanied by an extensive corneal ulcer with acute graft-versus-host disease (GVHD) after cord blood stem cell transplantation (CBSCT). The histopathology of the pseudomembrane and the ocular changes following its excision were investigated specifically. One week after the excision of pseudomembrane, the extensive corneal epithelial defects had totally disappeared. Pseudomembrane excision may be an effective method of treatment in corneal epithelial defects observed after GVHD.

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KW - Corneal ulcer

KW - Graft-versus-host disease

KW - Pseudomembrane

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Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation: Therapeutic challenges

Abstract

Keywords

ASJC Scopus subject areas

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