Omega-3 fatty acid metabolism and regulation of inflammation

Yosuke Isobe; Makoto Arita

doi:10.1007/978-4-431-55669-5_11

Omega-3 fatty acid metabolism and regulation of inflammation

Yosuke Isobe, Makoto Arita

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Abstract

Increasing evidence from both human and animal studies has demonstrated that omega-3 polyunsaturated fatty acids (PUFAs), primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can suppress inflammation and play a beneficial role in a variety of inflammation-related human diseases, such as inflammatory bowel disease, rheumatoid arthritis, asthma, cancer, and cardiovascular diseases. Omega-3 PUFAs serve as substrates for the production of potent bioactive anti-inflammatory lipid mediators such as resolvins. Herein wereview recent advances in understanding the formation and action of these mediators, especially focusing on the LC-ESI-MS/MS-based lipidomics approach and on recently identified bioactive compounds with potent anti-inflammatory properties.

Original language	English
Title of host publication	Bioactive Lipid Mediators
Subtitle of host publication	Current Reviews and Protocols
Publisher	Springer Japan
Pages	155-162
Number of pages	8
ISBN (Electronic)	9784431556695
ISBN (Print)	9784431556688
DOIs	https://doi.org/10.1007/978-4-431-55669-5_11
Publication status	Published - 2015 Jan 1
Externally published	Yes

Keywords

Anti-inflammation
LC-MS/MS
Lipid mediator
Lipidomics
Lipoxygenase
Omega-3 PUFA

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-4-431-55669-5_11

Cite this

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title = "Omega-3 fatty acid metabolism and regulation of inflammation ",

abstract = "Increasing evidence from both human and animal studies has demonstrated that omega-3 polyunsaturated fatty acids (PUFAs), primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can suppress inflammation and play a beneficial role in a variety of inflammation-related human diseases, such as inflammatory bowel disease, rheumatoid arthritis, asthma, cancer, and cardiovascular diseases. Omega-3 PUFAs serve as substrates for the production of potent bioactive anti-inflammatory lipid mediators such as resolvins. Herein wereview recent advances in understanding the formation and action of these mediators, especially focusing on the LC-ESI-MS/MS-based lipidomics approach and on recently identified bioactive compounds with potent anti-inflammatory properties.",

keywords = "Anti-inflammation, LC-MS/MS, Lipid mediator, Lipidomics, Lipoxygenase, Omega-3 PUFA",

author = "Yosuke Isobe and Makoto Arita",

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AU - Isobe, Yosuke

AU - Arita, Makoto

N1 - Publisher Copyright: © Springer Japan 2015.

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Y1 - 2015/1/1

N2 - Increasing evidence from both human and animal studies has demonstrated that omega-3 polyunsaturated fatty acids (PUFAs), primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can suppress inflammation and play a beneficial role in a variety of inflammation-related human diseases, such as inflammatory bowel disease, rheumatoid arthritis, asthma, cancer, and cardiovascular diseases. Omega-3 PUFAs serve as substrates for the production of potent bioactive anti-inflammatory lipid mediators such as resolvins. Herein wereview recent advances in understanding the formation and action of these mediators, especially focusing on the LC-ESI-MS/MS-based lipidomics approach and on recently identified bioactive compounds with potent anti-inflammatory properties.

AB - Increasing evidence from both human and animal studies has demonstrated that omega-3 polyunsaturated fatty acids (PUFAs), primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can suppress inflammation and play a beneficial role in a variety of inflammation-related human diseases, such as inflammatory bowel disease, rheumatoid arthritis, asthma, cancer, and cardiovascular diseases. Omega-3 PUFAs serve as substrates for the production of potent bioactive anti-inflammatory lipid mediators such as resolvins. Herein wereview recent advances in understanding the formation and action of these mediators, especially focusing on the LC-ESI-MS/MS-based lipidomics approach and on recently identified bioactive compounds with potent anti-inflammatory properties.

KW - Anti-inflammation

KW - LC-MS/MS

KW - Lipid mediator

KW - Lipidomics

KW - Lipoxygenase

KW - Omega-3 PUFA

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DO - 10.1007/978-4-431-55669-5_11

M3 - Chapter

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EP - 162

BT - Bioactive Lipid Mediators

PB - Springer Japan

ER -

Omega-3 fatty acid metabolism and regulation of inflammation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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