Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1

Hiroyuki Seki; Yukako Tani; Makoto Arita

doi:10.1016/j.prostaglandins.2009.03.002

Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1

Hiroyuki Seki, Yukako Tani, Makoto Arita

Research output: Contribution to journal › Review article › peer-review

99 Citations (Scopus)

Abstract

Inflammation is a defensive response to injury and infection, but excessive or inappropriate inflammation contributes to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of omega-3 polyunsaturated fatty acids (PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) indicate their beneficial impact on human diseases in which inflammation is suspected as a key component of the pathogenesis. Although the mechanism of EPA and DHA action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 PUFA-derived mediators including resolvins and protectins with potent anti-inflammatory and pro-resolving properties are produced. In this review, we provide an overview of the formation and actions of EPA-derived anti-inflammatory lipid mediator resolvin E1.

Original language	English
Pages (from-to)	126-130
Number of pages	5
Journal	Prostaglandins and Other Lipid Mediators
Volume	89
Issue number	3-4
DOIs	https://doi.org/10.1016/j.prostaglandins.2009.03.002
Publication status	Published - 2009 Sept
Externally published	Yes

Keywords

Inflammation
Lipidomics
Omega-3 PUFA
Resolvins

ASJC Scopus subject areas

Biochemistry
Physiology
Pharmacology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.prostaglandins.2009.03.002

Cite this

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title = "Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1",

abstract = "Inflammation is a defensive response to injury and infection, but excessive or inappropriate inflammation contributes to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of omega-3 polyunsaturated fatty acids (PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) indicate their beneficial impact on human diseases in which inflammation is suspected as a key component of the pathogenesis. Although the mechanism of EPA and DHA action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 PUFA-derived mediators including resolvins and protectins with potent anti-inflammatory and pro-resolving properties are produced. In this review, we provide an overview of the formation and actions of EPA-derived anti-inflammatory lipid mediator resolvin E1.",

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T1 - Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1

AU - Seki, Hiroyuki

AU - Tani, Yukako

AU - Arita, Makoto

PY - 2009/9

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N2 - Inflammation is a defensive response to injury and infection, but excessive or inappropriate inflammation contributes to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of omega-3 polyunsaturated fatty acids (PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) indicate their beneficial impact on human diseases in which inflammation is suspected as a key component of the pathogenesis. Although the mechanism of EPA and DHA action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 PUFA-derived mediators including resolvins and protectins with potent anti-inflammatory and pro-resolving properties are produced. In this review, we provide an overview of the formation and actions of EPA-derived anti-inflammatory lipid mediator resolvin E1.

AB - Inflammation is a defensive response to injury and infection, but excessive or inappropriate inflammation contributes to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of omega-3 polyunsaturated fatty acids (PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) indicate their beneficial impact on human diseases in which inflammation is suspected as a key component of the pathogenesis. Although the mechanism of EPA and DHA action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 PUFA-derived mediators including resolvins and protectins with potent anti-inflammatory and pro-resolving properties are produced. In this review, we provide an overview of the formation and actions of EPA-derived anti-inflammatory lipid mediator resolvin E1.

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KW - Lipidomics

KW - Omega-3 PUFA

KW - Resolvins

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Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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