Omeprazole, a Proton Pump Inhibitor, Reduces the Secretion, Synthesis and Gene Expression of Pepsinogen in the Rat Stomach

Nobuyuki Kakei; Masao Ichinose; Shinko Tsukada; Masae Tatematsu; Noriaki Tezuka; Naohisa Yahagi; Masashi Matsushima; Kazumasa Miki; Kiyoshi Kurokawa; Kenji Takahashi; Hhiroshi Fukamachi

doi:10.1006/bbrc.1993.2143

Omeprazole, a Proton Pump Inhibitor, Reduces the Secretion, Synthesis and Gene Expression of Pepsinogen in the Rat Stomach

Nobuyuki Kakei, Masao Ichinose, Shinko Tsukada, Masae Tatematsu, Noriaki Tezuka, Naohisa Yahagi, Masashi Matsushima, Kazumasa Miki, Kiyoshi Kurokawa, Kenji Takahashi, Hhiroshi Fukamachi

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Omeprazole, a proton pump inhibitor, dose-dependently inhibited pepsinogen secretion as well as acid secretion in the rat glandular stomach. The reduction in the secretion was rapid and was followed by a decrease in the mRNA levels. The inhibitory effect of omeprazole on pepsinogen secretion and its effect on the mRNA level showed similar dose-response relationship, suggesting that pepsinogen secretion and the gene expression are regulated coordinately. Consistent with the reduction in the mRNA levels, protein synthesis was reduced. However, intracellular stores of pepsinogen increased in pepsinogen-producing cells, indicating that the inhibitory effect of omeprazole on pepsinogen secretion is greater than on its synthesis. Reducing the secretion, synthesis and gene expression of pepsinogen, omeprazole has a potent effect on pepsinogen-producing cells in vivo, as well as on parietal cells, in the rat glandular stomach.

Original language	English
Pages (from-to)	997-1004
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	195
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1993.2143
Publication status	Published - 1993 Sept 15
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Kakei, N., Ichinose, M., Tsukada, S., Tatematsu, M., Tezuka, N., Yahagi, N., Matsushima, M., Miki, K., Kurokawa, K., Takahashi, K., & Fukamachi, H. (1993). Omeprazole, a Proton Pump Inhibitor, Reduces the Secretion, Synthesis and Gene Expression of Pepsinogen in the Rat Stomach. Biochemical and Biophysical Research Communications, 195(2), 997-1004. https://doi.org/10.1006/bbrc.1993.2143

Kakei, N, Ichinose, M, Tsukada, S, Tatematsu, M, Tezuka, N, Yahagi, N, Matsushima, M, Miki, K, Kurokawa, K, Takahashi, K & Fukamachi, H 1993, 'Omeprazole, a Proton Pump Inhibitor, Reduces the Secretion, Synthesis and Gene Expression of Pepsinogen in the Rat Stomach', Biochemical and Biophysical Research Communications, vol. 195, no. 2, pp. 997-1004. https://doi.org/10.1006/bbrc.1993.2143

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abstract = "Omeprazole, a proton pump inhibitor, dose-dependently inhibited pepsinogen secretion as well as acid secretion in the rat glandular stomach. The reduction in the secretion was rapid and was followed by a decrease in the mRNA levels. The inhibitory effect of omeprazole on pepsinogen secretion and its effect on the mRNA level showed similar dose-response relationship, suggesting that pepsinogen secretion and the gene expression are regulated coordinately. Consistent with the reduction in the mRNA levels, protein synthesis was reduced. However, intracellular stores of pepsinogen increased in pepsinogen-producing cells, indicating that the inhibitory effect of omeprazole on pepsinogen secretion is greater than on its synthesis. Reducing the secretion, synthesis and gene expression of pepsinogen, omeprazole has a potent effect on pepsinogen-producing cells in vivo, as well as on parietal cells, in the rat glandular stomach.",

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AU - Tatematsu, Masae

AU - Tezuka, Noriaki

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AU - Matsushima, Masashi

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AU - Takahashi, Kenji

AU - Fukamachi, Hhiroshi

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Omeprazole, a Proton Pump Inhibitor, Reduces the Secretion, Synthesis and Gene Expression of Pepsinogen in the Rat Stomach

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