On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen

Tomomi Murayama; Mio Tsuchiya; Koki Yoshida; Yuta Kurashina; Hiroaki Onoe

doi:10.1109/MEMS51782.2021.9375291

On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen

Tomomi Murayama, Mio Tsuchiya, Koki Yoshida, Yuta Kurashina, Hiroaki Onoe

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper describes a new fabrication method of microgel beads crosslinked by rapid temperature change using a centrifugal microfluidic device with a heating system and liquid nitrogen. Previously, materials for fabricating microgel beads with centrifugal microfluidic systems is limited to only sodium alginate solution. By using our proposed method, microgel beads could be fabricated by rapidly cooling pre-gel droplet ejected by centrifugal force. We succeeded in fabricating agarose microgel beads by rapid gelation in the liquid nitrogen. Our fabrication method will expand the variety of materials for the centrifugal microfluidic microgel beads fabrication method and possible applications including biosensors, tissue engineering and drug delivery systems.

Original language	English
Title of host publication	34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1027-1030
Number of pages	4
ISBN (Electronic)	9781665419123
DOIs	https://doi.org/10.1109/MEMS51782.2021.9375291
Publication status	Published - 2021 Jan 25
Event	34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021 - Virtual, Gainesville, United States Duration: 2021 Jan 25 → 2021 Jan 29

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2021-January
ISSN (Print)	1084-6999

Conference

Conference	34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021
Country/Territory	United States
City	Virtual, Gainesville
Period	21/1/25 → 21/1/29

Keywords

Agarose
Centrifugal force
Gelling by temperature
Heater device
Microgel beads

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMS51782.2021.9375291

Cite this

Murayama, T., Tsuchiya, M., Yoshida, K., Kurashina, Y., & Onoe, H. (2021). On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen. In 34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021 (pp. 1027-1030). Article 9375291 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2021-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS51782.2021.9375291

On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen. / Murayama, Tomomi; Tsuchiya, Mio; Yoshida, Koki et al.
34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021. Institute of Electrical and Electronics Engineers Inc., 2021. p. 1027-1030 9375291 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2021-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Murayama, T, Tsuchiya, M, Yoshida, K, Kurashina, Y & Onoe, H 2021, On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen. in 34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021., 9375291, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2021-January, Institute of Electrical and Electronics Engineers Inc., pp. 1027-1030, 34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021, Virtual, Gainesville, United States, 21/1/25. https://doi.org/10.1109/MEMS51782.2021.9375291

Murayama T, Tsuchiya M, Yoshida K, Kurashina Y, Onoe H. On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen. In 34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021. Institute of Electrical and Electronics Engineers Inc. 2021. p. 1027-1030. 9375291. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS51782.2021.9375291

Murayama, Tomomi ; Tsuchiya, Mio ; Yoshida, Koki et al. / On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen. 34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021. Institute of Electrical and Electronics Engineers Inc., 2021. pp. 1027-1030 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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title = "On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen",

abstract = "This paper describes a new fabrication method of microgel beads crosslinked by rapid temperature change using a centrifugal microfluidic device with a heating system and liquid nitrogen. Previously, materials for fabricating microgel beads with centrifugal microfluidic systems is limited to only sodium alginate solution. By using our proposed method, microgel beads could be fabricated by rapidly cooling pre-gel droplet ejected by centrifugal force. We succeeded in fabricating agarose microgel beads by rapid gelation in the liquid nitrogen. Our fabrication method will expand the variety of materials for the centrifugal microfluidic microgel beads fabrication method and possible applications including biosensors, tissue engineering and drug delivery systems.",

keywords = "Agarose, Centrifugal force, Gelling by temperature, Heater device, Microgel beads",

author = "Tomomi Murayama and Mio Tsuchiya and Koki Yoshida and Yuta Kurashina and Hiroaki Onoe",

note = "Funding Information: This work was partly supported by JKA and its promotion funds from KEIRIN RACE from JKA, Japan. Publisher Copyright: {\textcopyright} 2021 IEEE.; 34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021 ; Conference date: 25-01-2021 Through 29-01-2021",

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AU - Onoe, Hiroaki

PY - 2021/1/25

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AB - This paper describes a new fabrication method of microgel beads crosslinked by rapid temperature change using a centrifugal microfluidic device with a heating system and liquid nitrogen. Previously, materials for fabricating microgel beads with centrifugal microfluidic systems is limited to only sodium alginate solution. By using our proposed method, microgel beads could be fabricated by rapidly cooling pre-gel droplet ejected by centrifugal force. We succeeded in fabricating agarose microgel beads by rapid gelation in the liquid nitrogen. Our fabrication method will expand the variety of materials for the centrifugal microfluidic microgel beads fabrication method and possible applications including biosensors, tissue engineering and drug delivery systems.

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On-The-Fly Rapid-Cooling Gelation of Microgel Beads in Centrifugal Microfluidic Device with Liquid Nitrogen

Abstract

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Conference

Keywords

ASJC Scopus subject areas

Access to Document

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