Abstract
The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such " oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.
| Original language | English |
|---|---|
| Pages (from-to) | 3652-3658 |
| Number of pages | 7 |
| Journal | Journal of Clinical Investigation |
| Volume | 123 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2013 Sept 3 |
ASJC Scopus subject areas
- Medicine(all)
