Oncometabolites: Linking altered metabolism with cancer

Ming Yang, Tomoyoshi Soga, Patrick J. Pollard

Research output: Contribution to journalReview articlepeer-review

297 Citations (Scopus)


The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such " oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.

Original languageEnglish
Pages (from-to)3652-3658
Number of pages7
JournalJournal of Clinical Investigation
Issue number9
Publication statusPublished - 2013 Sept 3

ASJC Scopus subject areas

  • Medicine(all)


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