Opioid modulation of vasopressin secretion in conscious rats

Takayuki Yamada, Kazuwa Nakao, Hiroshi Itoh, Gotaro Shirakami, Akira Sugawara, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Narito Morii, Shozo Shiono, Hiroo Imura

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.

Original languageEnglish
Pages (from-to)361-367
Number of pages7
JournalClinical and Experimental Hypertension
Issue numberS1
Publication statusPublished - 1988
Externally publishedYes


  • Blood pressure
  • Carbachol
  • Heart rate
  • Leumorphin
  • Naloxone Nicotine
  • Opioid peptide
  • Vasopressin

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology


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