Opioid modulation of vasopressin secretion in conscious rats

Takayuki Yamada; Kazuwa Nakao; Hiroshi Itoh; Gotaro Shirakami; Akira Sugawara; Yoshihiko Saito; Masashi Mukoyama; Hiroshi Arai; Kiminori Hosoda; Narito Morii; Shozo Shiono; Hiroo Imura

doi:10.3109/10641968809075991

Opioid modulation of vasopressin secretion in conscious rats

Takayuki Yamada, Kazuwa Nakao, Hiroshi Itoh, Gotaro Shirakami, Akira Sugawara, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Narito Morii, Shozo Shiono, Hiroo Imura

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.

Original language	English
Pages (from-to)	361-367
Number of pages	7
Journal	Clinical and Experimental Hypertension
Volume	A10
Issue number	S1
DOIs	https://doi.org/10.3109/10641968809075991
Publication status	Published - 1988
Externally published	Yes

Keywords

Blood pressure
Carbachol
Heart rate
Leumorphin
Naloxone Nicotine
Opioid peptide
Vasopressin

ASJC Scopus subject areas

Internal Medicine
Physiology

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10.3109/10641968809075991

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title = "Opioid modulation of vasopressin secretion in conscious rats",

abstract = "To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.",

keywords = "Blood pressure, Carbachol, Heart rate, Leumorphin, Naloxone Nicotine, Opioid peptide, Vasopressin",

author = "Takayuki Yamada and Kazuwa Nakao and Hiroshi Itoh and Gotaro Shirakami and Akira Sugawara and Yoshihiko Saito and Masashi Mukoyama and Hiroshi Arai and Kiminori Hosoda and Narito Morii and Shozo Shiono and Hiroo Imura",

note = "Funding Information: We thank Ms Hiroko Tabata, Ms Atsuko Furu and Ms Ikuyo Yoshida for the excellent secretarial assistance. This work was supported in part by research grant from Japan Tobacco Inc.",

year = "1988",

doi = "10.3109/10641968809075991",

language = "English",

volume = "A10",

pages = "361--367",

journal = "Clinical and Experimental Hypertension",

issn = "1064-1963",

publisher = "Informa Healthcare",

number = "S1",

}

TY - JOUR

T1 - Opioid modulation of vasopressin secretion in conscious rats

AU - Yamada, Takayuki

AU - Nakao, Kazuwa

AU - Itoh, Hiroshi

AU - Shirakami, Gotaro

AU - Sugawara, Akira

AU - Saito, Yoshihiko

AU - Mukoyama, Masashi

AU - Arai, Hiroshi

AU - Hosoda, Kiminori

AU - Morii, Narito

AU - Shiono, Shozo

AU - Imura, Hiroo

N1 - Funding Information: We thank Ms Hiroko Tabata, Ms Atsuko Furu and Ms Ikuyo Yoshida for the excellent secretarial assistance. This work was supported in part by research grant from Japan Tobacco Inc.

PY - 1988

Y1 - 1988

N2 - To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.

AB - To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.

KW - Blood pressure

KW - Carbachol

KW - Heart rate

KW - Leumorphin

KW - Naloxone Nicotine

KW - Opioid peptide

KW - Vasopressin

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U2 - 10.3109/10641968809075991

DO - 10.3109/10641968809075991

M3 - Article

C2 - 3243002

AN - SCOPUS:0024272783

SN - 1064-1963

VL - A10

SP - 361

EP - 367

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

IS - S1

ER -

Opioid modulation of vasopressin secretion in conscious rats

Abstract

Keywords

ASJC Scopus subject areas

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