Optic nerve involvement of Waldenström's macroglobulinemia: With autopsy findings

Hiroko Nishida, Risa Hashida, Mami Hatano, Masao Hori, Katsuyuki Obara

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1 Citation (Scopus)


Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve.

Original languageEnglish
Pages (from-to)1299-1302
Number of pages4
JournalNeurological Sciences
Issue number8
Publication statusPublished - 2014 Aug


  • Autopsy
  • Lymphoplasmacytic lymphoma
  • Optic nerve
  • Visual loss
  • Waldenström's macroglobulinemia

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health


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