Optical property change of blood on an optical window boundary by 660-nm band laser irradiation

Mei Takahashi, Arisa Ito, Tsunenori Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We studied an optical interaction on an optical window and blood boundary during the CW laser irradiation in 660 nm band until blood charring occurrence. We previously reported that a pre-charring optical behavior may be detected by diffuse-reflected-light power time-history. The aim of this study is to measure absorption coefficient (μ a) and reduced scattering coefficient (μ' s) of a blood model to explain this pre-charring optical behavior. The blood model sandwiched between 2 glass slides to simulate the interface between blood and the optical window was used. A double integrating sphere system was constructed. The red laser in 660 nm band was irradiated to the sandwiched blood model. Fourty W/cm 2 in irradiance was used as the maximum irradiance during irradiation via the laser catheter in vivo. μ a and μ' s in the irradiated laser wavelength were measured continuously until blood charring occurrence using inverse adding doubling analysis. Continuous μ a increase of 5-10% from the initial value until charring was observed. Decrease of μ' s with 8-10% during 15-30 s before charring following broad peak was obtained. We think these μ a and μ' s changes may explain the pre-charring optical behavior detected by the diffuse-reflected-light power time-history in our reported study.

Original languageEnglish
Title of host publicationOptical Interactions with Tissue and Cells XXIII
Publication statusPublished - 2012
Externally publishedYes
EventOptical Interactions with Tissue and Cells XXIII - San Francisco, CA, United States
Duration: 2012 Jan 232012 Jan 25

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherOptical Interactions with Tissue and Cells XXIII
Country/TerritoryUnited States
CitySan Francisco, CA


  • blood charring
  • double integrating sphere
  • inverse adding doubling analysis
  • optical coefficient

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Optical property change of blood on an optical window boundary by 660-nm band laser irradiation'. Together they form a unique fingerprint.

Cite this