Optogenetics research using the mouse as a model system

Kenji F. Tanaka

doi:10.1007/978-4-431-55516-2_15

Optogenetics research using the mouse as a model system

Kenji F. Tanaka

Division of Brain Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Smooth progress in the field of optogenetic research can be, as the suffix ‘-genetics’ indicates, expected using biological models that provide conditions suitable for genetic control or gene manipulation. The artificial expression of opsin molecules is expected to be carried out smoothly in mice compared with rats or non-human primates because of established inheritable genetic modification technologies in this species. However, when compared with the nematode or the fly, there are still many difficulties in the expression of opsin in mice if flexible gene manipulation is attempted.

Original language	English
Title of host publication	Optogenetics
Subtitle of host publication	Light-Sensing Proteins and their Applications
Publisher	Springer Japan
Pages	227-240
Number of pages	14
ISBN (Electronic)	9784431555162
ISBN (Print)	9784431555155
DOIs	https://doi.org/10.1007/978-4-431-55516-2_15
Publication status	Published - 2015 Jan 1

Keywords

BAC transgenic
Cre-loxP system
KENGE-tet
Mouse genetics
Tet-system
β-actin gene

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-4-431-55516-2_15

Cite this

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Optogenetics research using the mouse as a model system

Abstract

Keywords

ASJC Scopus subject areas

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