Oral administration of resveratrol or lactic acid bacterium improves lens elasticity

Hayato Nagashima, Nobunari Sasaki, Sachie Amano, Shigeru Nakamura, Motoshi Hayano, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia. Although near vision impairment is a social issue affecting the length of healthy life expectancy and productivity of elderly people, an effective treatment to improve near vision has not yet become available. Here we examined the effect of Enterococcus faecium WB2000, Lactobacillus pentosus TJ515, and resveratrol on lens elasticity in rats, where the stiffness of the ocular lens increases exponentially during the aging process. A combination of WB2000 and resveratrol improved lens elasticity not only in the long term but also with just short-term treatment. In addition, TJ515 decreased stiffness in the eye lens with long-term treatment. Therefore, the oral administration of WB2000 and resveratrol or TJ515 may be a potential approach for managing the progression of near vision impairment.

Original languageEnglish
Article number2174
JournalScientific reports
Issue number1
Publication statusPublished - 2021 Dec
Externally publishedYes

ASJC Scopus subject areas

  • General


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