Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice

T. H. Kuo; T. Kubota; M. Watanabe; T. Furukawa; S. Kase; H. Tanino; H. Nishibori; Yoshirou Saikawa; T. Teramoto; K. Ihsibiki; M. Kitajima; R. M. Hoffman

Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice

T. H. Kuo, T. Kubota, M. Watanabe, T. Furukawa, S. Kase, H. Tanino, H. Nishibori, Yoshirou Saikawa, T. Teramoto, K. Ihsibiki, M. Kitajima, R. M. Hoffman

Law School

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 10⁶ tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.

Original language	English
Pages (from-to)	1407-1410
Number of pages	4
Journal	Anticancer research
Volume	12
Issue number	5
Publication status	Published - 1992 Jan 1

Keywords

Orthotopic reconstitution
SCID mouse
Small-cell lung carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice",

abstract = "We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 106 tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.",

keywords = "Orthotopic reconstitution, SCID mouse, Small-cell lung carcinoma",

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language = "English",

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TY - JOUR

T1 - Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice

AU - Kuo, T. H.

AU - Kubota, T.

AU - Watanabe, M.

AU - Furukawa, T.

AU - Kase, S.

AU - Tanino, H.

AU - Nishibori, H.

AU - Saikawa, Yoshirou

AU - Teramoto, T.

AU - Ihsibiki, K.

AU - Kitajima, M.

AU - Hoffman, R. M.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 106 tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.

AB - We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 106 tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.

KW - Orthotopic reconstitution

KW - SCID mouse

KW - Small-cell lung carcinoma

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AN - SCOPUS:0026439346

SN - 0250-7005

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JO - Anticancer research

JF - Anticancer research

IS - 5

ER -

Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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