Osteoporosis associated with rheumatoid arthritis

Hideto Kameda, Tsutomu Takeuchi

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Patients with rheumatoid arthritis(RA) develop both generalized and periarticular osteoporosis. Both of them are believed to be associated with increased production of inflammatory cytokines(TNF alpha, IL-1 beta, IL-6) and increased formation and activation of osteoclasts. Whether glucocorticoids work positively or negatively on generalized/periarticular osteoporosis is still controversial. RANKL has been shown to be expressed on T cells and fibroblast-like cells in the synovium, thus 'RANKL-RANK' pathway is likely to play an important role in periarticular osteoporosis and bone erosion as well as generalized osteoporosis. Among various therapies for generalized/periarticular osteoporosis in RA, anti-cytokine antibodies/antagonists and osteoclast inhibitors including bisphosphonates are promising.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number2
Publication statusPublished - 2003 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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