TY - JOUR
T1 - Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation
AU - Kobayashi, Ryoji
AU - Mitsui, Tetsuo
AU - Fujita, Naoto
AU - Osumi, Tomoo
AU - Aoki, Tomohiro
AU - Aoki, Kazunari
AU - Suzuki, Ritsuro
AU - Fukuda, Takahiro
AU - Miyamoto, Toshihiro
AU - Kato, Koji
AU - Nakamae, Hirohisa
AU - Goto, Hiroaki
AU - Eto, Tetsuya
AU - Inoue, Masami
AU - Mori, Takehiko
AU - Terui, Kiminori
AU - Onizuka, Masahito
AU - Koh, Katsuyoshi
AU - Koga, Yuhki
AU - Ichinohe, Tatsuo
AU - Sawada, Akihisa
AU - Atsuta, Yoshiko
AU - Suzumiya, Junji
N1 - Funding Information:
This research is supported by the Practical Research for Innovative Cancer Control from the Japan Agency for Medical Research and Development, AMED.
Publisher Copyright:
© 2016, The Japanese Society of Hematology.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Several studies of patients with acute lymphoblastic leukemia and acute myeloid leukemia who received stem cell transplantation (SCT) have reported that adolescents and young adults (AYAs) experience higher transplant-related mortality than that in younger children. However, to the best of our knowledge, there have been no reports of a similar comparison of non-Hodgkin lymphoma (NHL) patients who received SCT. We analyzed 918 patients aged 30 years and younger who received their first stem cell transplantation for NHL. Of the allogeneic transplant patients, children and AYAs did not significantly differ in survival rate, event-free survival rate, relapse rate, or transplant-related mortality. However, 5-year transplant-related mortality after autologous transplantation was significantly higher in children than in AYAs (5.1% in children vs. 0.8% in AYAs, P = 0.0043). The cause of transplant-related death in three of four children was interstitial pneumonitis. In NHL patients, transplantation results in AYAs were not inferior than those in children.
AB - Several studies of patients with acute lymphoblastic leukemia and acute myeloid leukemia who received stem cell transplantation (SCT) have reported that adolescents and young adults (AYAs) experience higher transplant-related mortality than that in younger children. However, to the best of our knowledge, there have been no reports of a similar comparison of non-Hodgkin lymphoma (NHL) patients who received SCT. We analyzed 918 patients aged 30 years and younger who received their first stem cell transplantation for NHL. Of the allogeneic transplant patients, children and AYAs did not significantly differ in survival rate, event-free survival rate, relapse rate, or transplant-related mortality. However, 5-year transplant-related mortality after autologous transplantation was significantly higher in children than in AYAs (5.1% in children vs. 0.8% in AYAs, P = 0.0043). The cause of transplant-related death in three of four children was interstitial pneumonitis. In NHL patients, transplantation results in AYAs were not inferior than those in children.
KW - AYA
KW - Non-Hodgkin lymphoma
KW - Stem cell transplantation
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U2 - 10.1007/s12185-016-2120-1
DO - 10.1007/s12185-016-2120-1
M3 - Article
C2 - 27787746
AN - SCOPUS:84992707499
SN - 0925-5710
VL - 105
SP - 369
EP - 376
JO - International journal of hematology
JF - International journal of hematology
IS - 3
ER -