Outcome of Nonagenarians Undergoing Transfemoral Transcatheter Aortic Valve Replacement: A Nationwide Registry Analysis From Japan

Ryosuke Higuchi, Hiraku Kumamaru, Shun Kohsaka, Mike Saji, Itaru Takamisawa, Mamoru Nanasato, Tomoki Shimokawa, Hideyuki Shimizu, Morimasa Takayama

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Nonagenarians are a growing age group in patients undergoing transcatheter aortic valve replacement (TAVR); however, the appropriate use of TAVR in this population remains discussed because of their limited life expectancy and worse outcome reported. Objectives: The authors aimed to evaluate clinical characteristics and the prognostic impact of nonagenarians. Methods: We analyzed consecutive patients undergoing transfemoral TAVR and were registered in the nationwide registry for TAVR in Japan (Japanese Transcatheter Valvular Therapies registry) between 2013 and 2018. The rate of 30-day and 1-year mortality and composite adverse event, comprising all-cause death, all stroke, and life-threatening/major bleeding, were assessed. Results: Of the 15,028 registered patients during the study period, 2,215 (14.7%) were nonagenarians. Although the nonagenarians were less likely to have comorbid conditions (eg, diabetes mellitus and malignancy) than patients aged <90 y, they had a higher Society of Thoracic Surgeons risk score (8.8% vs 5.6%), mainly owing to their advanced age. The procedural characteristics were identical between 2 groups. The rate of 30-day mortality and composite endpoint was similar, whereas 1-year mortality and composite adverse events were increased among nonagenarians (10.3% vs 6.8% and 13.5% vs 9.2%, respectively), and nonagenarians were independently associated with these endpoints (HR: 1.21; 95% CI: 1.03-1.42; P = 0.023; HR: 1.24; 95% CI: 1.07-1.42; P = 0.004). Conclusions: Of the 15,028 TAVR procedures performed in Japan between 2013 and 2018, 14.7% were performed in nonagenarians. These patients were carefully selected by a multidisciplinary heart team and showed 21% and 24% increase of 1-year mortality and composite adverse outcome.

Original languageEnglish
Pages (from-to)856-864
Number of pages9
JournalJACC: Asia
Issue number7
Publication statusPublished - 2022 Dec


  • J-TVT registry
  • Japan
  • TAVR
  • elderly

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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