P300 component of event-related potentials in persons with asperger disorder

Akira Iwanami, Yuka Okajima, Haruhisa Ota, Masayuki Tani, Takashi Yamada, Bun Yamagata, Ryuichiro Hashimoto, Chieko Kanai, Osamu Takashio, Atsuko Inamoto, Taisei Ono, Yukiko Takayama, Nobumasa Kato

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


In the present study, we investigated auditory event-related potentials in adults with Asperger disorder and normal controls using an auditory oddball task and a novelty oddball task. Task performance and the latencies of P300 evoked by both target and novel stimuli in the two tasks did not differ between the two groups. Analysis of variance revealed that there was a significant interaction effect between group and electrode site on the mean amplitude of the P300 evoked by novel stimuli, which indicated that there was an altered distribution of the P300 in persons with Asperger disorder. In contrast, there was no significant interaction effect on the mean P300 amplitude elicited by target stimuli. Considering that P300 comprises two main subcomponents, frontal-central-dominant P3a and parietal-dominant P3b, our results suggested that persons with Asperger disorder have enhanced amplitude of P3a, which indicated activated prefrontal function in this task.

Original languageEnglish
Pages (from-to)493-499
Number of pages7
JournalJournal of Clinical Neurophysiology
Issue number5
Publication statusPublished - 2014
Externally publishedYes


  • Asperger disorder
  • ERP
  • P300
  • P3a
  • P3b
  • PDD

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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