p53 gene mutations in early colorectal carcinoma. de novo vs. adenoma‐carcinoma sequence

Hirotoshi Hasegawa, Masakazu Ueda, Kazuo Furukawa, Masahiko Watanabe, Tatsuo Teramoto, Makio Mukai, Masaki Kitajima

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


p53 gene mutations in early and advanced colorectal cancer were detected by PCR‐SSCP analysis. Early colorectal cancer was classified intode novo cancer and polyp‐forming cancer, respectively, according to morphology and presence of adenomatous components. A total of 94 paraffin‐embedded tissue specimens from patients with colorectal cancer were analysed.p53 gene mutations were detected in 40.0% (12/30) of de novo cancer, 36.7% (11/30) of polyp‐forming cancer, and 44% (15/34) of advanced cancer. p53 mutations were detected at a high frequency in both types of early colorectal cancer as well as in advanced cancer. No correlations were found between p53 mutations and clinicopathological data. Our data suggest that the p53 gene mutations occurred in the early colorectal cancer stage of carcinogenesis regardless of the pathway. © 1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalInternational Journal of Cancer
Issue number1
Publication statusPublished - 1995 Feb 20
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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