TY - JOUR
T1 - Pancreas fat and β cell mass in humans with and without diabetes
T2 - An analysis in the Japanese population
AU - Murakami, Rie
AU - Saisho, Yoshifumi
AU - Watanabe, Yuusuke
AU - Inaishi, Jun
AU - Tsuchiya, Tami
AU - Kou, Kinsei
AU - Sato, Seiji
AU - Kitago, Minoru
AU - Kitagawa, Yuko
AU - Yamada, Taketo
AU - Itoh, Hiroshi
N1 - Funding Information:
This study was supported by funding from the Japan Diabetes Foundation, Keio Gijuku Academic Development Funds, and Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (JSPS KAKENHI) Grant Number JP15K09399 (to Y.S.).
Publisher Copyright:
Copyright © 2017 Endocrine Society.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Context: The mechanisms by which b cell mass is reduced in patients with type 2 diabetes remain unclear. It has been postulated that ectopic fat deposits in the pancreas induce b cell apoptosis, leading to the development of diabetes. Objective: The aim of this study was to clarify the effects of intrapancreatic fat on b and a cell mass in humans with and without diabetes. Design and Subjects: Using our tissue database, pancreas sections of 72 Japanese nondiabetic (NDM) autopsy cases and 50 diabetic and 49 age- and body mass index (BMI)-matched NDM patients who underwent pancreatic surgery were analyzed. In addition to histological grading, intrapancreatic fat area (IPFA) was quantified as fractional intralobular, but not interlobular, fat area to the whole pancreas area. Results: Although IPFA was positively correlated with age and BMI, there was no significant difference in IPFA between cases with and without diabetes. Moreover, no association was found between IPFA and either b or a cell area, or glycated hemoglobin. Conclusion: These findings suggest that pancreatic fat deposits have little effect on b cell mass and the development of diabetes in humans.
AB - Context: The mechanisms by which b cell mass is reduced in patients with type 2 diabetes remain unclear. It has been postulated that ectopic fat deposits in the pancreas induce b cell apoptosis, leading to the development of diabetes. Objective: The aim of this study was to clarify the effects of intrapancreatic fat on b and a cell mass in humans with and without diabetes. Design and Subjects: Using our tissue database, pancreas sections of 72 Japanese nondiabetic (NDM) autopsy cases and 50 diabetic and 49 age- and body mass index (BMI)-matched NDM patients who underwent pancreatic surgery were analyzed. In addition to histological grading, intrapancreatic fat area (IPFA) was quantified as fractional intralobular, but not interlobular, fat area to the whole pancreas area. Results: Although IPFA was positively correlated with age and BMI, there was no significant difference in IPFA between cases with and without diabetes. Moreover, no association was found between IPFA and either b or a cell area, or glycated hemoglobin. Conclusion: These findings suggest that pancreatic fat deposits have little effect on b cell mass and the development of diabetes in humans.
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U2 - 10.1210/jc.2017-00828
DO - 10.1210/jc.2017-00828
M3 - Article
C2 - 28633420
AN - SCOPUS:85030791017
SN - 0021-972X
VL - 102
SP - 3251
EP - 3260
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -
