Papillary thyroid carcinoma without metastases manifesting as an autonomously functioning thyroid nodule

Takafumi Majima, Kentaro Doi, Yasato Komatsu, Hiroshi Itoh, Atsushi Fukao, Michika Shigemoto, Chieko Takagi, Jerry Corners, Naomi Mizuta, Ryohei Kato, Kazuwa Nakao

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


A 59-year-old woman with papillary thyroid carcinoma inside of an autonomously functioning thyroid nodule is described in this report. The patient was referred to our clinic because of rapid weight loss and swelling on the left side of the neck. Ultrasonography of the thyroid demonstrated a nonhomogeneous nodule in the lower part of an enlarged left lobe. Both 99mTc and 123I thyroid scintigraphic imaging showed a hot area corresponding to the nodule with lower uptake in the remaining thyroid tissue. Histopathological examination of the nodule revealed papillary adenocarcinoma, and the immunohistochemistry proved weak but positive staining for triiodothyronine and thyroxine. Based on these findings, the nodule was diagnosed as a functioning papillary adenocarcinoma. Although thyroid carcinoma manifesting as a hot nodule on the radionuclide isotope scan is an extremely rare occurrence, the current case is clinically important because it suggests that the diagnosis of a hot nodule cannot always rule out thyroid carcinoma in the nodule, and that even a hot nodule requires careful management so that the malignancy is not overlooked.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalEndocrine journal
Issue number3
Publication statusPublished - 2005 Jun
Externally publishedYes


  • Autonomously functioning thyroid nodule
  • Hot nodule
  • Hyperfunctioning thyroid carcinoma
  • Metastasis
  • Papillary thyroid carcinoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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