Paraneoplastic pemphigus: An association with fludarabine?

C. Gooptu; T. J. Littlewood; P. Frith; C. C. Lyon; A. J. Carmichael; S. Oliwiecki; A. Macwhannell; M. Amagai; T. Hashimoto; D. Dean; J. Allen; F. Wojnarowska

doi:10.1046/j.1365-2133.2001.04244.x

Paraneoplastic pemphigus: An association with fludarabine?

C. Gooptu, T. J. Littlewood, P. Frith, C. C. Lyon, A. J. Carmichael, S. Oliwiecki, A. Macwhannell, M. Amagai, T. Hashimoto, D. Dean, J. Allen, F. Wojnarowska

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Abstract

Paraneoplastic pemphigus is a relatively recently described immunobullous disease with characteristic features. We report three cases of paraneoplastic pemphigus in adult men with chronic lymphocytic leukaemia arising within a week of completion of treatment with fludarabine. In all cases, withdrawal of fludarabine and treatment of the blistering was associated with marked cutaneous improvement. Fludarabine, a synthetic nucleoside analogue, which has only been available in Britain since 1994, is known to be associated with autoimmune phenomena and may have been involved in the development of paraneoplastic pemphigus in these cases.

Original language	English
Pages (from-to)	1255-1261
Number of pages	7
Journal	British Journal of Dermatology
Volume	144
Issue number	6
DOIs	https://doi.org/10.1046/j.1365-2133.2001.04244.x
Publication status	Published - 2001

Keywords

Chronic lymphocytic leukaemia
Fludarabine
Paraneoplastic pemphigus

ASJC Scopus subject areas

Dermatology

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10.1046/j.1365-2133.2001.04244.x

Cite this

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title = "Paraneoplastic pemphigus: An association with fludarabine?",

abstract = "Paraneoplastic pemphigus is a relatively recently described immunobullous disease with characteristic features. We report three cases of paraneoplastic pemphigus in adult men with chronic lymphocytic leukaemia arising within a week of completion of treatment with fludarabine. In all cases, withdrawal of fludarabine and treatment of the blistering was associated with marked cutaneous improvement. Fludarabine, a synthetic nucleoside analogue, which has only been available in Britain since 1994, is known to be associated with autoimmune phenomena and may have been involved in the development of paraneoplastic pemphigus in these cases.",

keywords = "Chronic lymphocytic leukaemia, Fludarabine, Paraneoplastic pemphigus",

author = "C. Gooptu and Littlewood, {T. J.} and P. Frith and Lyon, {C. C.} and Carmichael, {A. J.} and S. Oliwiecki and A. Macwhannell and M. Amagai and T. Hashimoto and D. Dean and J. Allen and F. Wojnarowska",

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T2 - An association with fludarabine?

AU - Gooptu, C.

AU - Littlewood, T. J.

AU - Frith, P.

AU - Lyon, C. C.

AU - Carmichael, A. J.

AU - Oliwiecki, S.

AU - Macwhannell, A.

AU - Amagai, M.

AU - Hashimoto, T.

AU - Dean, D.

AU - Allen, J.

AU - Wojnarowska, F.

PY - 2001

Y1 - 2001

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AB - Paraneoplastic pemphigus is a relatively recently described immunobullous disease with characteristic features. We report three cases of paraneoplastic pemphigus in adult men with chronic lymphocytic leukaemia arising within a week of completion of treatment with fludarabine. In all cases, withdrawal of fludarabine and treatment of the blistering was associated with marked cutaneous improvement. Fludarabine, a synthetic nucleoside analogue, which has only been available in Britain since 1994, is known to be associated with autoimmune phenomena and may have been involved in the development of paraneoplastic pemphigus in these cases.

KW - Chronic lymphocytic leukaemia

KW - Fludarabine

KW - Paraneoplastic pemphigus

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ER -

Paraneoplastic pemphigus: An association with fludarabine?

Abstract

Keywords

ASJC Scopus subject areas

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