@inproceedings{3ee51f4a511c4d9395e2496a4c2e652a,
title = "Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis",
abstract = "The concentration changes in oxygenated haemoglobin and deoxygenated haemoglobin in the brain cortex of guinea pigs associated with brain activation are measured from the multi-spectral images of the cortical tissue. The cortical tissue is observed through a thinned skull. The wavelength dependence of the optical path length is considered in the calculation of haemoglobin concentration. The results are compared with those obtained from the multi-spectral images of the exposed cortex to evaluate the influence of the thinned skull on the measurement of the concentration changes by multi-spectral imaging system. Although the skull thickness affected the sensitivity of the change in reflectance due to decrease in optical path in the cortical tissue, the influence of skull on the wavelength dependence of the optical path length can be ignored when the skull thickness is approximately less than 100 μm.",
keywords = "Cranial window, Multi-spectral imaging, Optical path length, Thinned skull",
author = "Koichiro Sakaguchi and Shunsuke Furukawa and Takushige Katsura and Kyoko Yamazaki and Hideo Kawaguchi and Atsushi Maki and Eiji Okada",
year = "2007",
language = "English",
isbn = "0819467731",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Diffuse Optical Imaging of Tissue",
note = "Diffuse Optical Imaging of Tissue ; Conference date: 19-06-2007 Through 21-06-2007",
}