Pathogenesis of cognitive impairment in multiple sclerosis

Research output: Contribution to journalArticlepeer-review


Around a half of multiple sclerosis (MS) patients suffer from cognitive impairment such as attention deficit. A similar impairment is already observable in one third of patients with clinical isolated syndrome, suggesting that the symptom cannot be solely explained by the accumulation of demyelinated lesions. Recently, several studies indicated that demyelination and atrophy in specific regions of the brain are related to the cognitive impairment, although those patients with brain and cognitive reserves are resistant to the development of such symptom. Aging, male sex and smoking increases whereas certain disease-modifying therapy decreases the risk of cognitive impairment in MS. Together, the development of cognitive impairment in MS appears to be determined by the balance between specific aggravating and protective factors.

Original languageEnglish
Pages (from-to)1063-1065
Number of pages3
JournalClinical Neurology
Issue number12
Publication statusPublished - 2014 Jan 1


  • Brain atrophy
  • Cognitive impairment
  • Demyelination
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology


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