Pathological complete response in advanced gastric carcinoma by S-1/CDDP combination chemotherapy

Fumiki Toriumi, Shigenori Ei, Hidena Takahashi, Rei Okada, Kyohei Masai, Mikiko Mito, Naoki Ishimaru, Katsuhiko Mizuno, Kan Handa, Takahiro Yamanashi, Yoshitomo Koshida, Hidetoshi Akamatsu, Katsuhiko Motegi, Toshihide Tajima, Kiyoshi Mukai, Yutaka Shimoyama

Research output: Contribution to journalArticlepeer-review


A 59-year-old woman was referred to our hospital for a close examination and treatment of an advanced gastric carcinoma. A physical examination and CT scan showed that the right cervical and axillar lymph nodes were swelling, and a histopathological examination of the axillar lymph node revealed metastatic growth of the gastric carcinoma (Stage IV). Then, we started S-1/CDDP combination chemotherapy. S-1 (80 mg/m2/day) was orally administered for 3 weeks followed by 2 weeks of rest, and CDDP (60 mg/m2) was administered by drip on day 8. Since the distant metastases were greatly reduced after 6 courses of combination therapy, a distal gastrectomy with lymph nodes dissection (D2) was performed. Histopathological examination of the resected tissues revealed no residual cancer cells, suggesting a pathologically complete response. The clinical course after the operation went well without any complications, and the patient is alive with no evidence of recurrence 1 year after surgery. S-1/CDDP combination chemotherapy appears to be one of the effective treatments for advanced gastric carcinoma.

Original languageEnglish
Pages (from-to)1183-1186
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Issue number7
Publication statusPublished - 2011 Jul 6
Externally publishedYes


  • CDDP
  • Gastric carcinoma
  • Pathological CR
  • S-1

ASJC Scopus subject areas

  • General Medicine


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