TY - JOUR
T1 - PEG-based nanocomposite hydrogel
T2 - Thermo-responsive sol-gel transition and degradation behavior controlled by the LA/GA ratio of PLGA-PEG-PLGA
AU - Kitagawa, Midori
AU - Maeda, Tomoki
AU - Hotta, Atsushi
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research (A) and by a Fund for the Promotion of Joint International Research (Fostering Joint International Research) (No. 15H02298 and No. 15KK0244 , respectively to A.H.) from the Japan Society for the Promotion of Science (JSPS: “KAKENHI”). A.H. is grateful to Prof. Glenn H. Fredrickson from the University of California, Santa Barbara for offering stimulating suggestions and encouragements.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/1
Y1 - 2018/1
N2 - The sol-gel transition behavior and the degradation behavior of the nanocomposites consisting of laponite clay nanoparticles and poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers (laponite/PLGA-PEG-PLGA nanocomposites) were studied changing the LA/GA ratios of the PLGA blocks in the PLGA-PEG-PLGA. The thermo-responsive sol-gel transition at the physiological temperature (25–37 °C) was observed using the PLGA-PEG-PLGA with a high PEG/PLGA ratio of ∼0.8 regardless of the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). The decomposition rates of the laponite/PLGA-PEG-PLGA nanocomposites at 37 °C were regulated by adjusting the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). Specifically, ∼45% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratio of 1.1, while ∼30% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratios of 4.0 and 8.8.
AB - The sol-gel transition behavior and the degradation behavior of the nanocomposites consisting of laponite clay nanoparticles and poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers (laponite/PLGA-PEG-PLGA nanocomposites) were studied changing the LA/GA ratios of the PLGA blocks in the PLGA-PEG-PLGA. The thermo-responsive sol-gel transition at the physiological temperature (25–37 °C) was observed using the PLGA-PEG-PLGA with a high PEG/PLGA ratio of ∼0.8 regardless of the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). The decomposition rates of the laponite/PLGA-PEG-PLGA nanocomposites at 37 °C were regulated by adjusting the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). Specifically, ∼45% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratio of 1.1, while ∼30% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratios of 4.0 and 8.8.
KW - Biodegradable
KW - Nanocomposite
KW - PLGA-PEG-PLGA
KW - Thermo-responsive hydrogel
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U2 - 10.1016/j.polymdegradstab.2017.11.024
DO - 10.1016/j.polymdegradstab.2017.11.024
M3 - Article
AN - SCOPUS:85037990726
SN - 0141-3910
VL - 147
SP - 222
EP - 228
JO - Polymer Degradation and Stability
JF - Polymer Degradation and Stability
ER -