Perioperative clinical parameters associated with short-term mortality after colorectal perforation

Tadashi Matsuoka, Ryo Yamamoto, Kazuki Matsumura, Rie Kondo, Kenji Kobayashi, Alan Kawarai Lefor, Junichi Sasaki, Hiroharu Shinozaki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose: Although early prediction of mortality is useful for the management of patients with colorectal perforations, no significant perioperative predictive factors have been identified. The purpose of this study was to identify useful prognostic factors for patients with colorectal perforation. Methods: This single-center retrospective study included consecutive patients undergoing emergency surgery for colorectal perforation from January 2012 to December 2019. The primary outcome was combined 30 day and in-hospital mortality. Patient- and disease-related factors obtained perioperatively were evaluated for mortality prediction. A scoring system was developed to enhance clinical utility. Results: Overall, 146 patients were included and 20 (14%) died after surgery. Multivariate logistic regression identified five predictive factors: age, hemodialysis, uncommon perforation etiology, plasma albumin level, and decreased platelet count. The area under the receiver operating curve for the scoring system using these parameters was 0.894 (95% CI 0.835–0.952). Patients at high-risk of mortality were classified by the proposed score with a sensitivity of 90.0% and negative predictive value of 98.0%. Conclusion: This study identified five perioperative factors significantly associated with mortality of patients with colorectal perforation. Although these parameters predict mortality of patients with colorectal perforation using a score with high discrimination, further study is required to confirm these findings.

Original languageEnglish
Pages (from-to)3017-3024
Number of pages8
JournalEuropean Journal of Trauma and Emergency Surgery
Issue number4
Publication statusPublished - 2022 Aug


  • Coagulopathy
  • Colorectal perforation
  • Emergency surgery
  • Prognostic predictors

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Orthopedics and Sports Medicine
  • Critical Care and Intensive Care Medicine


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