Perivascular nitric oxide gradients normalize tumor vasculature

Satoshi Kashiwagi, Kosuke Tsukada, Lei Xu, Junichi Miyazaki, Sergey V. Kozin, James A. Tyrrell, William C. Sessa, Leo E. Gerweck, Rakesh K. Jain, Dai Fukumura

Research output: Contribution to journalArticlepeer-review

145 Citations (Scopus)


Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.

Original languageEnglish
Pages (from-to)255-257
Number of pages3
JournalNature medicine
Issue number3
Publication statusPublished - 2008 Mar
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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