Abstract
Aim: The aim of this phase I study was to adjust the dose of cisplatin as adjuvant combination chemotherapy with S-1 in an outpatient setting for gastric cancer.
Patients and Methods: The first course was initiated with S-1 monotherapy on days 1-28. From the second to the sixth course, S-1 was administered on days 1-28 and cisplatin was added on days 1, 15, and 29. The dose level of cisplatin was escalated as follows: 20 mg/m2 (level 1); 25 mg/m2 (level 2); 30 mg/m2 (level 3). Dose-limiting toxicity was a delay factor of the start of the next course due to incomplete recovery.
Results: The maximum tolerated and recommended doses were confirmed as level 3 and level 2, respectively.
Conclusion: Although further clinical trials are recommended to evaluate efficacy, this combination of S-1 plus cisplatin regimen is expected to become a standard adjuvant treatment for gastric cancer in the outpatient setting.
| Original language | English |
|---|---|
| Pages (from-to) | 467-472 |
| Number of pages | 6 |
| Journal | Anticancer research |
| Volume | 35 |
| Issue number | 1 |
| Publication status | Published - 2015 Jan 1 |
Keywords
- Adjuvant chemotherapy
- Cisplatin
- Gastric cancer
- Outpatient setting
- S-1
ASJC Scopus subject areas
- Oncology
- Cancer Research
