Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indica

Tatsuhiro Yamaguchi; Kazufumi Toume; Midori A. Arai; Firoj Ahmed; Samir K. Sadhu; Masami Ishibashi

doi:10.1177/1934578x1200700414

Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indica

Tatsuhiro Yamaguchi, Kazufumi Toume, Midori A. Arai, Firoj Ahmed, Samir K. Sadhu, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 - 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/β-catenin (TOP) transcriptional activity at 95 nM.

Original language	English
Pages (from-to)	475-477
Number of pages	3
Journal	Natural product communications
Volume	7
Issue number	4
DOIs	https://doi.org/10.1177/1934578x1200700414
Publication status	Published - 2012 Apr
Externally published	Yes

Keywords

Diterpenoid
Euphorbiaceae
Wnt signal

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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10.1177/1934578x1200700414

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abstract = "A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 - 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/β-catenin (TOP) transcriptional activity at 95 nM.",

keywords = "Diterpenoid, Euphorbiaceae, Wnt signal",

author = "Tatsuhiro Yamaguchi and Kazufumi Toume and Arai, {Midori A.} and Firoj Ahmed and Sadhu, {Samir K.} and Masami Ishibashi",

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AU - Yamaguchi, Tatsuhiro

AU - Toume, Kazufumi

AU - Arai, Midori A.

AU - Ahmed, Firoj

AU - Sadhu, Samir K.

AU - Ishibashi, Masami

PY - 2012/4

Y1 - 2012/4

N2 - A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 - 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/β-catenin (TOP) transcriptional activity at 95 nM.

AB - A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 - 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/β-catenin (TOP) transcriptional activity at 95 nM.

KW - Diterpenoid

KW - Euphorbiaceae

KW - Wnt signal

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JO - Natural product communications

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IS - 4

ER -

Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indica

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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