TY - JOUR
T1 - Phosphorylation of a new member of the bicarbonate cotransporter superfamily
AU - Hayashi, M.
N1 - Funding Information:
This study was supported in part by grants from the Ministry of Education, Science, and Culture and the Ministry of Health, Labour, and Welfare of Japan and a National grant-in-aid for the Establishment of High-Tech Research Center in a Private University.
PY - 2001
Y1 - 2001
N2 - Acid-base balance is regulated by cortical collecting duct cells in kidney, where the transporter functions of β-intercalated cells are controlled by such factors as isoproterenol, cyclic adenosine monophosphate (cAMP), and the protein kinase A (PKA) pathway. The apical anion exchanger (AE) in β-intercalated cells is thought to be involved in the secretion of bicarbonate into urine. In isolated cells, the Cl- channel was shown to be activated by isoproterenol via the PKA pathway. The importance of the PKA pathway and phosphorylation in the regulation of its transporter activity is not yet known.
AB - Acid-base balance is regulated by cortical collecting duct cells in kidney, where the transporter functions of β-intercalated cells are controlled by such factors as isoproterenol, cyclic adenosine monophosphate (cAMP), and the protein kinase A (PKA) pathway. The apical anion exchanger (AE) in β-intercalated cells is thought to be involved in the secretion of bicarbonate into urine. In isolated cells, the Cl- channel was shown to be activated by isoproterenol via the PKA pathway. The importance of the PKA pathway and phosphorylation in the regulation of its transporter activity is not yet known.
KW - Acid-base homeostasis
KW - Apical anion exchanger
KW - Chloride channel
KW - Intercalated cells
KW - Urinary acid secretion
KW - β-intercalated cells
UR - http://www.scopus.com/inward/record.url?scp=0034927116&partnerID=8YFLogxK
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U2 - 10.1046/j.1523-1755.2001.060002462.x
DO - 10.1046/j.1523-1755.2001.060002462.x
M3 - Article
C2 - 11473627
AN - SCOPUS:0034927116
SN - 0085-2538
VL - 60
SP - 462
EP - 465
JO - Kidney international
JF - Kidney international
IS - 2
ER -