Photoacoustic imaging of cerebral blood vessels in a rat for monitoring drug delivery to the brain tissue

Ryota Watanabe; Shunichi Sato; Yasuyuki Tsunoi; Satoko Kawauchi; Hiroshi Ashida; Mitsuhiro Terakawa

doi:10.11239/jsmbe.52.O-110

Photoacoustic imaging of cerebral blood vessels in a rat for monitoring drug delivery to the brain tissue

Ryota Watanabe, Shunichi Sato, Yasuyuki Tsunoi, Satoko Kawauchi, Hiroshi Ashida, Mitsuhiro Terakawa

Department of Electronics and Electrical Engineering

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In general, it is difficult to deliver a drug to the brain transvascularly due to the blood-brain barrier. To develop a method for drug delivery to the brain, a modality that enables imaging both of the cerebral blood vessels and a drug is needed. In this study, we developed a compact photoacoustic imaging system, by which label-free imaging of the cerebral blood vessels in a rat was performed in vivo. By compensating the attenuation of excitation light in brain tissue, blood vessels with diameters larger than 50 μm were visualized in the depth range up to ~2 mm.

Original language	English
Pages (from-to)	O-110-O-111
Journal	Transactions of Japanese Society for Medical and Biological Engineering
Volume	52
DOIs	https://doi.org/10.11239/jsmbe.52.O-110
Publication status	Published - 2014 Aug 17

Keywords

Blood Brain Barrier
Blood vessels
Drug delivery
Optical fiber
Photoacoustic imaging

ASJC Scopus subject areas

Biomedical Engineering

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10.11239/jsmbe.52.O-110

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title = "Photoacoustic imaging of cerebral blood vessels in a rat for monitoring drug delivery to the brain tissue",

abstract = "In general, it is difficult to deliver a drug to the brain transvascularly due to the blood-brain barrier. To develop a method for drug delivery to the brain, a modality that enables imaging both of the cerebral blood vessels and a drug is needed. In this study, we developed a compact photoacoustic imaging system, by which label-free imaging of the cerebral blood vessels in a rat was performed in vivo. By compensating the attenuation of excitation light in brain tissue, blood vessels with diameters larger than 50 μm were visualized in the depth range up to ~2 mm.",

keywords = "Blood Brain Barrier, Blood vessels, Drug delivery, Optical fiber, Photoacoustic imaging",

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T1 - Photoacoustic imaging of cerebral blood vessels in a rat for monitoring drug delivery to the brain tissue

AU - Watanabe, Ryota

AU - Sato, Shunichi

AU - Tsunoi, Yasuyuki

AU - Kawauchi, Satoko

AU - Ashida, Hiroshi

AU - Terakawa, Mitsuhiro

PY - 2014/8/17

Y1 - 2014/8/17

N2 - In general, it is difficult to deliver a drug to the brain transvascularly due to the blood-brain barrier. To develop a method for drug delivery to the brain, a modality that enables imaging both of the cerebral blood vessels and a drug is needed. In this study, we developed a compact photoacoustic imaging system, by which label-free imaging of the cerebral blood vessels in a rat was performed in vivo. By compensating the attenuation of excitation light in brain tissue, blood vessels with diameters larger than 50 μm were visualized in the depth range up to ~2 mm.

AB - In general, it is difficult to deliver a drug to the brain transvascularly due to the blood-brain barrier. To develop a method for drug delivery to the brain, a modality that enables imaging both of the cerebral blood vessels and a drug is needed. In this study, we developed a compact photoacoustic imaging system, by which label-free imaging of the cerebral blood vessels in a rat was performed in vivo. By compensating the attenuation of excitation light in brain tissue, blood vessels with diameters larger than 50 μm were visualized in the depth range up to ~2 mm.

KW - Blood Brain Barrier

KW - Blood vessels

KW - Drug delivery

KW - Optical fiber

KW - Photoacoustic imaging

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Photoacoustic imaging of cerebral blood vessels in a rat for monitoring drug delivery to the brain tissue

Abstract

Keywords

ASJC Scopus subject areas

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