Pilot study on sentinel node biopsy in breast cancer

Shigeru Imoto, Hiroyoshi Fukukita, Kohji Murakami, Hiroshi Ikeda, Noriyuki Moriyama

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Background and Objectives: Sentinel node biopsy (SNB) in breast cancer using indigo carmine was started in January 1998, and this method has proved feasible and reliable. From our initial experience, sentinel lymph nodes (SLNs) were identified in 65 of 88 cases of breast cancer (74%). Methods: Lymphatic mapping in breast cancer was assessed using radionuclide, technetium-99m human serum albumin or technetium-99m tin colloid. A pilot study on SNB with dye or a combined method was performed between August 1998 and January 1999. Results: SLNs were identified in 55 of 59 cases (93%). False-negative SLNs were found in 2 cases. The sensitivity and accuracy in all cases were 92% and 96%. SLNs in 52 cases were also diagnosed by immediate frozen sectioning. The sensitivity and accuracy were 89% and 96%. Conclusions: SNB in the combined method was the best way to identify SLNs in breast cancer. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalJournal of Surgical Oncology
Issue number3
Publication statusPublished - 2000
Externally publishedYes


  • Breast cancer
  • Indigo carmine
  • Lymphatic mapping
  • Sentinel lymph nodes
  • Sentinel node biopsy

ASJC Scopus subject areas

  • Surgery
  • Oncology


Dive into the research topics of 'Pilot study on sentinel node biopsy in breast cancer'. Together they form a unique fingerprint.

Cite this