Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases

Ning Qu; Mingli Xu; Izuru Mizoguchi; Jun Ichi Furusawa; Kotaro Kaneko; Kazunori Watanabe; Junichiro Mizuguchi; Masahiro Itoh; Yutaka Kawakami; Takayuki Yoshimoto

doi:10.1155/2013/968549

Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases

Ning Qu, Mingli Xu, Izuru Mizoguchi, Jun Ichi Furusawa, Kotaro Kaneko, Kazunori Watanabe, Junichiro Mizuguchi, Masahiro Itoh, Yutaka Kawakami, Takayuki Yoshimoto

Research output: Contribution to journal › Review article › peer-review

144 Citations (Scopus)

Abstract

T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.

Original language	English
Article number	968549
Journal	Clinical and Developmental Immunology
Volume	2013
DOIs	https://doi.org/10.1155/2013/968549
Publication status	Published - 2013
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1155/2013/968549

Cite this

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title = "Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases",

abstract = "T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.",

author = "Ning Qu and Mingli Xu and Izuru Mizoguchi and Furusawa, {Jun Ichi} and Kotaro Kaneko and Kazunori Watanabe and Junichiro Mizuguchi and Masahiro Itoh and Yutaka Kawakami and Takayuki Yoshimoto",

year = "2013",

doi = "10.1155/2013/968549",

language = "English",

volume = "2013",

journal = "Clinical and Developmental Immunology",

issn = "1740-2522",

publisher = "Hindawi Publishing Corporation",

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TY - JOUR

T1 - Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases

AU - Qu, Ning

AU - Xu, Mingli

AU - Mizoguchi, Izuru

AU - Furusawa, Jun Ichi

AU - Kaneko, Kotaro

AU - Watanabe, Kazunori

AU - Mizuguchi, Junichiro

AU - Itoh, Masahiro

AU - Kawakami, Yutaka

AU - Yoshimoto, Takayuki

PY - 2013

Y1 - 2013

N2 - T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.

AB - T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.

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DO - 10.1155/2013/968549

M3 - Review article

C2 - 23956763

AN - SCOPUS:84881502993

SN - 1740-2522

VL - 2013

JO - Clinical and Developmental Immunology

JF - Clinical and Developmental Immunology

M1 - 968549

ER -

Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases

Abstract

ASJC Scopus subject areas

UN SDGs

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