PLAC1, an Xq26 gene with placenta-specific expression

Massimo Cocchia, Reid Huber, Serafino Pantano, Ellson Y. Chen, Peter Ma, Antonino Forabosco, Minoru S.H. Ko, David Schlessinger

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)


A novel human X-linked gene shows placenta-specific expression and has been named PLAC1. The gene maps 65 kb telomeric to HPRT at Xq26 and has been completely sequenced at the cDNA and genomic levels. The mouse orthologue Plac1 maps to the syntenically equivalent region of the mouse X chromosome. In situ hybridization studies with the antisense mRNA during mouse embryogenesis detect Plac1 expression from 7.5 dpc (days postcoitum) to 14.5 dpc in ectoplacental cone, giant cells, and labyrinthine trophoblasts. The putative human and murine PLAC1 proteins are 60% identical and 77% homologous. Both include a signal peptide and a peptide sequence also found in an interaction domain of the ZP3 (zona pellucida 3) protein. These results make PLAC1 a marker for placental development, with a possible role in the establishment of the mother-fetus interface. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)305-312
Number of pages8
Issue number3
Publication statusPublished - 2000 Sept 15
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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