Plasma substance P level in patients with schizophrenia: A cross-sectional study

Takuto Ishida, Hiroyuki Uchida, Takefumi Suzuki, Shinichiro Nakajima, Koichiro Watanabe, Haruo Kashima

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Aspiration pneumonia is a serious health concern in older patients with schizophrenia. In this study, we examined clinical and demographic variables that could impact the plasma substance P level, which is a useful predictive biomarker of aspiration. Thirty-four patients were included (mean age ± SD: 70.9 ± 10.8 years). A greater number of cigarettes/day and a higher antipsychotic dosage were found to be associated with a lower plasma substance P level, while age showed a trend-level effect. This finding suggests the need for intensive observation for prevention of aspiration pneumonia in heavy smokers who are receiving a higher antipsychotic dose in this senior population.

Original languageEnglish
Pages (from-to)526-528
Number of pages3
JournalPsychiatry and Clinical Neurosciences
Issue number5
Publication statusPublished - 2011 Aug


  • antipsychotics
  • aspiration pneumonia
  • schizophrenia
  • smoking
  • substance P

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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