Plasma substance P level in patients with schizophrenia: A cross-sectional study

Takuto Ishida; Hiroyuki Uchida; Takefumi Suzuki; Shinichiro Nakajima; Koichiro Watanabe; Haruo Kashima

doi:10.1111/j.1440-1819.2011.02244.x

Plasma substance P level in patients with schizophrenia: A cross-sectional study

Takuto Ishida, Hiroyuki Uchida, Takefumi Suzuki, Shinichiro Nakajima, Koichiro Watanabe, Haruo Kashima

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Aspiration pneumonia is a serious health concern in older patients with schizophrenia. In this study, we examined clinical and demographic variables that could impact the plasma substance P level, which is a useful predictive biomarker of aspiration. Thirty-four patients were included (mean age ± SD: 70.9 ± 10.8 years). A greater number of cigarettes/day and a higher antipsychotic dosage were found to be associated with a lower plasma substance P level, while age showed a trend-level effect. This finding suggests the need for intensive observation for prevention of aspiration pneumonia in heavy smokers who are receiving a higher antipsychotic dose in this senior population.

Original language	English
Pages (from-to)	526-528
Number of pages	3
Journal	Psychiatry and Clinical Neurosciences
Volume	65
Issue number	5
DOIs	https://doi.org/10.1111/j.1440-1819.2011.02244.x
Publication status	Published - 2011 Aug

Keywords

antipsychotics
aspiration pneumonia
schizophrenia
smoking
substance P

ASJC Scopus subject areas

Neuroscience(all)
Neurology
Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1440-1819.2011.02244.x

Cite this

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abstract = "Aspiration pneumonia is a serious health concern in older patients with schizophrenia. In this study, we examined clinical and demographic variables that could impact the plasma substance P level, which is a useful predictive biomarker of aspiration. Thirty-four patients were included (mean age ± SD: 70.9 ± 10.8 years). A greater number of cigarettes/day and a higher antipsychotic dosage were found to be associated with a lower plasma substance P level, while age showed a trend-level effect. This finding suggests the need for intensive observation for prevention of aspiration pneumonia in heavy smokers who are receiving a higher antipsychotic dose in this senior population.",

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T2 - A cross-sectional study

AU - Ishida, Takuto

AU - Uchida, Hiroyuki

AU - Suzuki, Takefumi

AU - Nakajima, Shinichiro

AU - Watanabe, Koichiro

AU - Kashima, Haruo

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KW - antipsychotics

KW - aspiration pneumonia

KW - schizophrenia

KW - smoking

KW - substance P

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Plasma substance P level in patients with schizophrenia: A cross-sectional study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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