PLP-I: A novel prolactin-like gene in rodents

Yoshiki Hiraoka; Motoyuki Ogawa; Yukinao Sakai; Yuji Takeuchi; Naoki Komatsu; Masahide Shiozawa; Kiyoo Tanabe; Sadakazu Aiso

doi:10.1016/S0167-4781(99)00160-8

PLP-I: A novel prolactin-like gene in rodents

Yoshiki Hiraoka, Motoyuki Ogawa, Yukinao Sakai, Yuji Takeuchi, Naoki Komatsu, Masahide Shiozawa, Kiyoo Tanabe, Sadakazu Aiso

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In this report, we describe molecular cloning and characterization of cDNAs encoding a novel rat prolactin-like protein. The rat cDNAs were isolated from the decidua and the gene was named PLP-I. cDNAs for the mouse equivalent were also cloned by the cross-hybridization technique. Pregnancy-specific expression of the rat PLP-I gene was observed in the rat placenta by Northern analysis. Location of signal peptide cleavage sites in rat and mouse pre-PLP-I proteins was predicted using a theoretical method. A molecular phylogenetic tree for the growth hormone-prolactin superfamily including the novel member, PLP-I, constructed using the neighbor-joining method, places rat/mouse PLP-I closest to rat/mouse placental lactogen I and II. Copyright (C) 1999 Elsevier Science B.V.

Original language	English
Pages (from-to)	291-297
Number of pages	7
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1447
Issue number	2-3
DOIs	https://doi.org/10.1016/S0167-4781(99)00160-8
Publication status	Published - 1999 Oct 28
Externally published	Yes

Keywords

Decidua
Phylogenetic tree
Prolactin
cDNA

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

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10.1016/S0167-4781(99)00160-8

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title = "PLP-I: A novel prolactin-like gene in rodents",

abstract = "In this report, we describe molecular cloning and characterization of cDNAs encoding a novel rat prolactin-like protein. The rat cDNAs were isolated from the decidua and the gene was named PLP-I. cDNAs for the mouse equivalent were also cloned by the cross-hybridization technique. Pregnancy-specific expression of the rat PLP-I gene was observed in the rat placenta by Northern analysis. Location of signal peptide cleavage sites in rat and mouse pre-PLP-I proteins was predicted using a theoretical method. A molecular phylogenetic tree for the growth hormone-prolactin superfamily including the novel member, PLP-I, constructed using the neighbor-joining method, places rat/mouse PLP-I closest to rat/mouse placental lactogen I and II. Copyright (C) 1999 Elsevier Science B.V.",

keywords = "Decidua, Phylogenetic tree, Prolactin, cDNA",

author = "Yoshiki Hiraoka and Motoyuki Ogawa and Yukinao Sakai and Yuji Takeuchi and Naoki Komatsu and Masahide Shiozawa and Kiyoo Tanabe and Sadakazu Aiso",

note = "Funding Information: This work was supported in part by a National Grant-in-Aid for the Establishment of High-Tech Research Center in a Private University from the Ministry of Education, Science and Culture to S.A. and Grants-in-Aids from the Ministry of Education, Science and Culture to S.A. and Y.H., by Keio Gakuji Fukuzawa Memorial Funds for Advancement of Education and Research and Keio Gakuji Academic Developmental Funds from Keio University to S.A. and Y.H.",

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doi = "10.1016/S0167-4781(99)00160-8",

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AU - Hiraoka, Yoshiki

AU - Ogawa, Motoyuki

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AU - Takeuchi, Yuji

AU - Komatsu, Naoki

AU - Shiozawa, Masahide

AU - Tanabe, Kiyoo

AU - Aiso, Sadakazu

N1 - Funding Information: This work was supported in part by a National Grant-in-Aid for the Establishment of High-Tech Research Center in a Private University from the Ministry of Education, Science and Culture to S.A. and Grants-in-Aids from the Ministry of Education, Science and Culture to S.A. and Y.H., by Keio Gakuji Fukuzawa Memorial Funds for Advancement of Education and Research and Keio Gakuji Academic Developmental Funds from Keio University to S.A. and Y.H.

PY - 1999/10/28

Y1 - 1999/10/28

N2 - In this report, we describe molecular cloning and characterization of cDNAs encoding a novel rat prolactin-like protein. The rat cDNAs were isolated from the decidua and the gene was named PLP-I. cDNAs for the mouse equivalent were also cloned by the cross-hybridization technique. Pregnancy-specific expression of the rat PLP-I gene was observed in the rat placenta by Northern analysis. Location of signal peptide cleavage sites in rat and mouse pre-PLP-I proteins was predicted using a theoretical method. A molecular phylogenetic tree for the growth hormone-prolactin superfamily including the novel member, PLP-I, constructed using the neighbor-joining method, places rat/mouse PLP-I closest to rat/mouse placental lactogen I and II. Copyright (C) 1999 Elsevier Science B.V.

AB - In this report, we describe molecular cloning and characterization of cDNAs encoding a novel rat prolactin-like protein. The rat cDNAs were isolated from the decidua and the gene was named PLP-I. cDNAs for the mouse equivalent were also cloned by the cross-hybridization technique. Pregnancy-specific expression of the rat PLP-I gene was observed in the rat placenta by Northern analysis. Location of signal peptide cleavage sites in rat and mouse pre-PLP-I proteins was predicted using a theoretical method. A molecular phylogenetic tree for the growth hormone-prolactin superfamily including the novel member, PLP-I, constructed using the neighbor-joining method, places rat/mouse PLP-I closest to rat/mouse placental lactogen I and II. Copyright (C) 1999 Elsevier Science B.V.

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KW - Prolactin

KW - cDNA

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PLP-I: A novel prolactin-like gene in rodents

Abstract

Keywords

ASJC Scopus subject areas

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