TY - JOUR
T1 - Polybrominated diphenyl ethers and persistent organochlorines in Japanese human adipose tissues
AU - Kunisue, Tatsuya
AU - Takayanagi, Nozomi
AU - Isobe, Tomohiko
AU - Takahashi, Shin
AU - Nose, Masato
AU - Yamada, Taketo
AU - Komori, Hiroaki
AU - Arita, Norimasa
AU - Ueda, Norifumi
AU - Tanabe, Shinsuke
N1 - Funding Information:
We express our heartfelt gratitude to the families of the donors. We also thank the doctors and medical officers in Ehime University Graduate School of Medicine and School of Medicine, Keio University for their help in sample collection. The authors are thankful to Dr. An. Subramanian (CMES, Ehime University) for critical reading of this manuscript. This study was supported by the Global Environmental Research Fund (RF-064) and the Waste Management Research Grant (K1821 and K1836) from the Ministry of the Environment and by Grants-in-Aid for Scientific Research (A) (No.16201014) and (B) (No. 18310046), Young Scientists (B) (Project 19780239) and “Global COE Program” from the Ministry of Education, Culture, Sports, Science and Technology, and Japan Society for the Promotion of Science (JSPS), and by Grants-in-Aid for Scientific Research (H14-013) from the Ministry of Health, Labour and Welfare, Japan.
PY - 2007/11
Y1 - 2007/11
N2 - The present study determined concentrations of polybrominated diphenyl ethers (PBDEs) and persistent organochlorines (OCs) in Japanese human adipose tissues collected during 2003-2004. Concentrations of PBDEs in adipose tissues were 1-2 orders of magnitude lower than those of OCs. However, observed PBDE congener levels in this study were relatively higher than those in Japanese human adipose tissues collected during 2000 reported previously, while OC levels were comparable to those in specimens collected during 1999 reported by our group. In addition, no age-dependent accumulation of PBDEs was observed, while OC levels except chlordane compounds increased with age. These results indicate recent human exposure to PBDEs in Japan. Among PBDE congeners accumulated in Japanese adipose tissues, BDE-153 was dominant, but this trend was different from those in human milk (BDE-47) and blood (BDE-209) reported previously in Japan, implying the congener-specific kinetics in human bodies. The significant positive correlations between PBDEs and OCs were observed in Japanese adipose tissues, indicating the similar exposure route of these contaminants for Japanese citizens, probably via fish intake.
AB - The present study determined concentrations of polybrominated diphenyl ethers (PBDEs) and persistent organochlorines (OCs) in Japanese human adipose tissues collected during 2003-2004. Concentrations of PBDEs in adipose tissues were 1-2 orders of magnitude lower than those of OCs. However, observed PBDE congener levels in this study were relatively higher than those in Japanese human adipose tissues collected during 2000 reported previously, while OC levels were comparable to those in specimens collected during 1999 reported by our group. In addition, no age-dependent accumulation of PBDEs was observed, while OC levels except chlordane compounds increased with age. These results indicate recent human exposure to PBDEs in Japan. Among PBDE congeners accumulated in Japanese adipose tissues, BDE-153 was dominant, but this trend was different from those in human milk (BDE-47) and blood (BDE-209) reported previously in Japan, implying the congener-specific kinetics in human bodies. The significant positive correlations between PBDEs and OCs were observed in Japanese adipose tissues, indicating the similar exposure route of these contaminants for Japanese citizens, probably via fish intake.
KW - Human adipose tissue
KW - Japan
KW - OCs
KW - PBDEs
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U2 - 10.1016/j.envint.2007.06.006
DO - 10.1016/j.envint.2007.06.006
M3 - Article
C2 - 17651803
AN - SCOPUS:34748908020
SN - 0160-4120
VL - 33
SP - 1048
EP - 1056
JO - Environment international
JF - Environment international
IS - 8
ER -