Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys)

Tomohiro Honda; Yukihiko Dan; Noriko Koyabu; Hisakazu Ohtani; Yasufumi Sawada; Ichiro Ieiri; Kenji Otsubo; Shun Higuchi

doi:10.2133/dmpk.17.479

Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys)

Tomohiro Honda, Yukihiko Dan, Noriko Koyabu, Hisakazu Ohtani, Yasufumi Sawada, Ichiro Ieiri, Kenji Otsubo, Shun Higuchi

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5' -ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.

Original language	English
Pages (from-to)	479-481
Number of pages	3
Journal	Drug Metabolism And Pharmacokinetics
Volume	17
Issue number	5
DOIs	https://doi.org/10.2133/dmpk.17.479
Publication status	Published - 2002
Externally published	Yes

Keywords

G325A
amino acid substitution
exon 5
multidrug-resistance 1 (P-glycoprotein, MDR1, ABCB1)
single nucleotide polymorphism (SNP)

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2133/dmpk.17.479

Cite this

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title = "Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys)",

abstract = "We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5' -ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.",

keywords = "G325A, amino acid substitution, exon 5, multidrug-resistance 1 (P-glycoprotein, MDR1, ABCB1), single nucleotide polymorphism (SNP)",

author = "Tomohiro Honda and Yukihiko Dan and Noriko Koyabu and Hisakazu Ohtani and Yasufumi Sawada and Ichiro Ieiri and Kenji Otsubo and Shun Higuchi",

year = "2002",

doi = "10.2133/dmpk.17.479",

language = "English",

volume = "17",

pages = "479--481",

journal = "Drug Metabolism And Pharmacokinetics",

issn = "1347-4367",

publisher = "Japanese Society for the Study of Xenobiotics",

number = "5",

}

TY - JOUR

T1 - Polymorphism of MDR1 Gene in Healthy Japanese Subjects

T2 - A Novel SNP with an Amino Acid Substitution (Glu108Lys)

AU - Honda, Tomohiro

AU - Dan, Yukihiko

AU - Koyabu, Noriko

AU - Ohtani, Hisakazu

AU - Sawada, Yasufumi

AU - Ieiri, Ichiro

AU - Otsubo, Kenji

AU - Higuchi, Shun

PY - 2002

Y1 - 2002

N2 - We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5' -ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.

AB - We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5' -ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.

KW - G325A

KW - amino acid substitution

KW - exon 5

KW - multidrug-resistance 1 (P-glycoprotein, MDR1, ABCB1)

KW - single nucleotide polymorphism (SNP)

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U2 - 10.2133/dmpk.17.479

DO - 10.2133/dmpk.17.479

M3 - Article

AN - SCOPUS:0141961080

SN - 1347-4367

VL - 17

SP - 479

EP - 481

JO - Drug Metabolism And Pharmacokinetics

JF - Drug Metabolism And Pharmacokinetics

IS - 5

ER -

Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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