TY - JOUR
T1 - Polysaccharide-Coated Liposome with Antimicrobial Agents Against Intracytoplasmic Pathogen and Fungus
AU - Kohno, Shigeru
AU - Miyazaki, Takashige
AU - Yamaguchi, Keizo
AU - Tanaka, Hikaru
AU - Hayashi, Toshiaki
AU - Hirota, Masaki
AU - Saito, Atsushi
AU - Hara, Kohei
AU - Sato, Toshinori
AU - Sunamoto, Junzo
PY - 1988/4
Y1 - 1988/4
N2 - Liposomes which are stabilized by being coated with polysaccharides such as amylopectin and mannan are concentrated in the lung and liver more than simple liposomes without any polysaccharide-coat. These polysaccharidecoated liposomes are easily internalized by macrophages. Amylopectin-coated liposome with ceftazidime (survival rate, 30%) was better than free ceftazidime alone (survival rate, 0%) for the treatment of Legionella pneumonia in guinea pigs. The antibiotic efficacy rate of polysaccharide-coated liposome bearing minocycline (MINO) or ampicillin (ABPC) was much better than that of free MINO or ABPC for the treatment of Listeria infection. These data suggest that polysaccharide-coated liposomes bearing antibiotics are excellent for intracytoplasmic pathogen especially in the reticuloendothelial system where a large population of phagocytes exist.
AB - Liposomes which are stabilized by being coated with polysaccharides such as amylopectin and mannan are concentrated in the lung and liver more than simple liposomes without any polysaccharide-coat. These polysaccharidecoated liposomes are easily internalized by macrophages. Amylopectin-coated liposome with ceftazidime (survival rate, 30%) was better than free ceftazidime alone (survival rate, 0%) for the treatment of Legionella pneumonia in guinea pigs. The antibiotic efficacy rate of polysaccharide-coated liposome bearing minocycline (MINO) or ampicillin (ABPC) was much better than that of free MINO or ABPC for the treatment of Listeria infection. These data suggest that polysaccharide-coated liposomes bearing antibiotics are excellent for intracytoplasmic pathogen especially in the reticuloendothelial system where a large population of phagocytes exist.
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U2 - 10.1177/088391158800300204
DO - 10.1177/088391158800300204
M3 - Article
AN - SCOPUS:0023765679
SN - 0883-9115
VL - 3
SP - 137
EP - 147
JO - Journal of Bioactive and Compatible Polymers
JF - Journal of Bioactive and Compatible Polymers
IS - 2
ER -