TY - JOUR
T1 - Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis
AU - Naganuma, Tatsuro
AU - Fujinami, Nodoka
AU - Arita, Makoto
N1 - Funding Information:
This study was supported by JSPS KAKENHI 20H00495 and RIKEN Pioneering Project “Glyco-Lipidologue Initiative.”
Publisher Copyright:
© 2022 The Pharmaceutical Society of Japan.
PY - 2022/8
Y1 - 2022/8
N2 - Epithelial tissues are mainly composed of epithelial cells, covering both internal and external surfaces of our body. To maintain epithelial homeostasis, cellular functions, such as proliferation, migration, and differentiation, are flexibly regulated in response to changes in the cellular status, thereby contributing to barrier formation, immune reaction, and wound closure. Polyunsaturated fatty acids (PUFAs) are precursors of various lipid mediators that maintain tissue homeostasis by exerting characteristic bioactivities. This review aimed to summarize the role of PUFA-derived lipid mediators in epithelial cell functions, mainly focusing on the epidermis, cornea, and intestinal epithelium.
AB - Epithelial tissues are mainly composed of epithelial cells, covering both internal and external surfaces of our body. To maintain epithelial homeostasis, cellular functions, such as proliferation, migration, and differentiation, are flexibly regulated in response to changes in the cellular status, thereby contributing to barrier formation, immune reaction, and wound closure. Polyunsaturated fatty acids (PUFAs) are precursors of various lipid mediators that maintain tissue homeostasis by exerting characteristic bioactivities. This review aimed to summarize the role of PUFA-derived lipid mediators in epithelial cell functions, mainly focusing on the epidermis, cornea, and intestinal epithelium.
KW - epithelium
KW - lipid mediator
KW - polyunsaturated fatty acid
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U2 - 10.1248/bpb.b22-00252
DO - 10.1248/bpb.b22-00252
M3 - Review article
C2 - 35908910
AN - SCOPUS:85135249361
SN - 0918-6158
VL - 45
SP - 998
EP - 1007
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
IS - 8
ER -