Polyurethane surface modification by graft polymerization of acrylamide for reduced protein adsorption and platelet adhesion

Keiji Fujimoto; Hideki Tadokoro; Yohichi Ueda; Yoshito Ikada

doi:10.1016/0142-9612(93)90147-T

Polyurethane surface modification by graft polymerization of acrylamide for reduced protein adsorption and platelet adhesion

Keiji Fujimoto, Hideki Tadokoro, Yohichi Ueda, Yoshito Ikada

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

Surface modification of polyurethane by glow-discharge treatment and subsequent graft polymerization of acrylamide was studied. The modified hydrophilic surfaces were characterized by the measurements of dynamic contact angle and ζ potentials and examined for protein adsorption behaviour and platelet adhesion. Data from in vitro and ex vivo experiments indicated a reduction of protein adsorption and platelet adhesion for the hydrophillic graft polymers, the extent of which was correlated to polymer graft density.

Original language	English
Pages (from-to)	442-448
Number of pages	7
Journal	Biomaterials
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/0142-9612(93)90147-T
Publication status	Published - 1993 May
Externally published	Yes

Keywords

Surface modification
graft polymerization
platelet adhesion
protein adsorption

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/0142-9612(93)90147-T

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abstract = "Surface modification of polyurethane by glow-discharge treatment and subsequent graft polymerization of acrylamide was studied. The modified hydrophilic surfaces were characterized by the measurements of dynamic contact angle and ζ potentials and examined for protein adsorption behaviour and platelet adhesion. Data from in vitro and ex vivo experiments indicated a reduction of protein adsorption and platelet adhesion for the hydrophillic graft polymers, the extent of which was correlated to polymer graft density.",

keywords = "Surface modification, graft polymerization, platelet adhesion, protein adsorption",

author = "Keiji Fujimoto and Hideki Tadokoro and Yohichi Ueda and Yoshito Ikada",

year = "1993",

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T1 - Polyurethane surface modification by graft polymerization of acrylamide for reduced protein adsorption and platelet adhesion

AU - Fujimoto, Keiji

AU - Tadokoro, Hideki

AU - Ueda, Yohichi

AU - Ikada, Yoshito

PY - 1993/5

Y1 - 1993/5

N2 - Surface modification of polyurethane by glow-discharge treatment and subsequent graft polymerization of acrylamide was studied. The modified hydrophilic surfaces were characterized by the measurements of dynamic contact angle and ζ potentials and examined for protein adsorption behaviour and platelet adhesion. Data from in vitro and ex vivo experiments indicated a reduction of protein adsorption and platelet adhesion for the hydrophillic graft polymers, the extent of which was correlated to polymer graft density.

AB - Surface modification of polyurethane by glow-discharge treatment and subsequent graft polymerization of acrylamide was studied. The modified hydrophilic surfaces were characterized by the measurements of dynamic contact angle and ζ potentials and examined for protein adsorption behaviour and platelet adhesion. Data from in vitro and ex vivo experiments indicated a reduction of protein adsorption and platelet adhesion for the hydrophillic graft polymers, the extent of which was correlated to polymer graft density.

KW - Surface modification

KW - graft polymerization

KW - platelet adhesion

KW - protein adsorption

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EP - 448

JO - Biomaterials

JF - Biomaterials

IS - 6

ER -

Polyurethane surface modification by graft polymerization of acrylamide for reduced protein adsorption and platelet adhesion

Abstract

Keywords

ASJC Scopus subject areas

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