Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder

Masaki Kodaira, Yoshitaka Iwadare, Hirokage Ushijima, Arata Oiji, Motoichiro Kato, Nobuhiro Sugiyama, Daimei Sasayama, Masahide Usami, Kyota Watanabe, Kazuhiko Saito

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Background: Several lines of evidence implicate orbitofrontal cortex dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD). The purpose of this study was to investigate neuropsychological dysfunction of the orbitofrontal cortex in children with OCD.Methods: The Iowa Gambling Task (IGT), which reflects orbitofrontal cortex function, and the Wisconsin Card Sorting Test (WCST), which is associated with functioning of the dorsolateral prefrontal cortex, were administered to 22 children with OCD and 22 healthy controls matched for gender, age, and intelligence.Results: OCD patients displayed poor performance on the IGT. In contrast, performance on the WCST was not impaired in OCD patients compared to controls.Conclusions: These findings are in line with previous studies demonstrating that OCD in childhood is associated with a dysfunction of orbitofrontal-striatal-thalamic circuitry.

Original languageEnglish
Article number25
JournalAnnals of General Psychiatry
Publication statusPublished - 2012 Oct 12
Externally publishedYes


  • Childhood-onset
  • Iowa gambling task
  • Obsessive-compulsive disorder
  • Orbitofrontal cortex
  • Wisconsin card sorting test

ASJC Scopus subject areas

  • Psychiatry and Mental health


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