Possible Involvement of Hypotension in Postprandial Headache: A Case Series

Tsubasa Takizawa, Mamoru Shibata, Takahiro Hiraide, Morinobu Seki, Shinichi Takahashi, Norihiro Suzuki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: It is commonly known that headaches are induced by intake of specific food, drink, and/or additive. In addition, some patients experience postprandial headache independent of ingestion of specific items. Currently, information on the pathophysiology underlying this particular type of headache is scarce. Case reports: We report two cases in which headaches were observed after each meal. Postprandial hypotension was demonstrated in both cases. Tonometry-based continuous blood pressure measurement during head-up tilt revealed sympathetic dysfunction. In one patient, meta-iodobenzylguanidine (MIBG) myocardial scintigraphy detected cardiac sympathetic denervation, and diagnosis of pure autonomic failure was made. In both cases, treatment of postprandial hypotension was effective in relieving postprandial headache. Discussion: The possibility of postprandial hypotension should be explored in patients with headache that occurs after meal. To this end, tonometry-based blood pressure measurement and MIBG myocardial scintigraphy may be useful diagnostic investigations. Treating postprandial hypotension may be effective in alleviating the symptoms.

Original languageEnglish
Pages (from-to)1443-1448
Number of pages6
Issue number9
Publication statusPublished - 2017 Oct


  • head-up tilt testing
  • headache induced by food and/or additive
  • meta-iodobenzylguanidine (MIBG) myocardial scintigraphy
  • postprandial hypotension

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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