Postmortem Diagnosis of Acute Megakaryocytic Leukemia Usefulness of lmmunohistochemistry and Tissue Hemogram

Akihiro Umezawa; Taketo Yamada; Yuuto Ogawa; Shigeru Kuramochi; Yonosuke Watanabe

doi:10.1111/j.1440-1827.1990.tb01618.x

Postmortem Diagnosis of Acute Megakaryocytic Leukemia Usefulness of lmmunohistochemistry and Tissue Hemogram

Akihiro Umezawa, Taketo Yamada, Yuuto Ogawa, Shigeru Kuramochi, Yonosuke Watanabe

Department of Pathology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)‐ positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa‐positive blasts and megakaryoblasts were deposited massively in lymph nodes. lmmunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultra‐structural platelet peroxidase in autopsy materials is difficult.

Original language	English
Pages (from-to)	693-698
Number of pages	6
Journal	Pathology international
Volume	40
Issue number	9
DOIs	https://doi.org/10.1111/j.1440-1827.1990.tb01618.x
Publication status	Published - 1990 Sept

Keywords

Acute megakaryocytic leukemia
Glycoprotein IIb/IIIa
Immunohistochemistry
Tissue hemogram

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1111/j.1440-1827.1990.tb01618.x

Cite this

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title = "Postmortem Diagnosis of Acute Megakaryocytic Leukemia Usefulness of lmmunohistochemistry and Tissue Hemogram",

abstract = "An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)‐ positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa‐positive blasts and megakaryoblasts were deposited massively in lymph nodes. lmmunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultra‐structural platelet peroxidase in autopsy materials is difficult.",

keywords = "Acute megakaryocytic leukemia, Glycoprotein IIb/IIIa, Immunohistochemistry, Tissue hemogram",

author = "Akihiro Umezawa and Taketo Yamada and Yuuto Ogawa and Shigeru Kuramochi and Yonosuke Watanabe",

year = "1990",

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T1 - Postmortem Diagnosis of Acute Megakaryocytic Leukemia Usefulness of lmmunohistochemistry and Tissue Hemogram

AU - Umezawa, Akihiro

AU - Yamada, Taketo

AU - Ogawa, Yuuto

AU - Kuramochi, Shigeru

AU - Watanabe, Yonosuke

PY - 1990/9

Y1 - 1990/9

N2 - An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)‐ positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa‐positive blasts and megakaryoblasts were deposited massively in lymph nodes. lmmunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultra‐structural platelet peroxidase in autopsy materials is difficult.

AB - An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)‐ positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa‐positive blasts and megakaryoblasts were deposited massively in lymph nodes. lmmunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultra‐structural platelet peroxidase in autopsy materials is difficult.

KW - Acute megakaryocytic leukemia

KW - Glycoprotein IIb/IIIa

KW - Immunohistochemistry

KW - Tissue hemogram

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Postmortem Diagnosis of Acute Megakaryocytic Leukemia Usefulness of lmmunohistochemistry and Tissue Hemogram

Abstract

Keywords

ASJC Scopus subject areas

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