TY - JOUR
T1 - Posttranscriptional Regulation of MicroRNA Biogenesis in Animals
AU - Siomi, Haruhiko
AU - Siomi, Mikiko C.
N1 - Funding Information:
The authors would like to thank members of the Siomi laboratory for discussions and three anonymous referees for their useful comments. We apologize to colleagues whose relevant primary publications were not cited because of space constraints. This work was supported by MEXT grants to H.S. and NEDO (New Energy and Industrial Technology Development Organization) grants to M.C.S. M.C.S. is supported by CREST from the Japanese Science and Technology Agency.
PY - 2010/5/14
Y1 - 2010/5/14
N2 - MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes by promoting degradation or repressing translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated, and regulation occurs both transcriptionally and posttranscriptionally. This regulation is crucial, as alteration of miRNA expression has been linked to human diseases, including several cancers. Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals.
AB - MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes by promoting degradation or repressing translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated, and regulation occurs both transcriptionally and posttranscriptionally. This regulation is crucial, as alteration of miRNA expression has been linked to human diseases, including several cancers. Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals.
UR - http://www.scopus.com/inward/record.url?scp=77951964981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951964981&partnerID=8YFLogxK
U2 - 10.1016/j.molcel.2010.03.013
DO - 10.1016/j.molcel.2010.03.013
M3 - Review article
C2 - 20471939
AN - SCOPUS:77951964981
SN - 1097-2765
VL - 38
SP - 323
EP - 332
JO - Molecular Cell
JF - Molecular Cell
IS - 3
ER -
